(Q21124649)

http://www.ebi.ac.uk/interpro/protein/P63316

EF-hand domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EF-Hand 1, calcium-binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

27 March 2018

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

27 March 2018

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

protein homodimerization activity

1 reference

8 April 2019

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

calcium-dependent protein binding

1 reference

27 March 2018

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

4 references

8 April 2019

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

4 references

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

actin filament binding

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

calcium-dependent protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

2 references

27 March 2018

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

27 March 2018

Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

cardiac Troponin complex

1 reference

8 April 2019

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

3 references

8 April 2019

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

regulation of muscle contraction

biological process

transition between fast and slow fiber

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

diaphragm contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

response to metal ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

ventricular cardiac muscle tissue morphogenesis

1 reference

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

IMP

muscle filament sliding

1 reference

8 April 2019

skeletal muscle contraction

TAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

cardiac muscle contraction

3 references

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

regulation of muscle contraction

3 references

8 April 2019

Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2051955

has part(s)

EF-hand domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63316

EF-hand 1, calcium-binding site

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63316

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

1 reference

9 August 2016