(Q21124872)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

receptor ligand activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

type I activin receptor binding

1 reference

24 April 2018

Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96S42&geneProductId=UniProtKB:Q96S42

morphogen activity

NAS

1 reference

8 April 2019

Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

transforming growth factor beta receptor binding

NAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

type I activin receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

3 references

8 April 2019

8 April 2019

Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

trophectodermal cellular morphogenesis

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

left lung morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

neural fold formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

maternal process involved in parturition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

cell fate commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

endoderm development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

transforming growth factor beta receptor signaling pathway involved in primitive streak formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

floor plate morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

endodermal cell differentiation

1 reference

8 April 2019

Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

embryonic pattern specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

polarity specification of proximal/distal axis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

digestive system development

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of cell-cell adhesion

1 reference

8 April 2019

Inhibition of Nodal suppresses angiogenesis and growth of human gliomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

lung development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

placenta development

1 reference

8 April 2019

Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

negative regulation of cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of pathway-restricted SMAD protein phosphorylation

1 reference

24 April 2018

Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96S42&geneProductId=UniProtKB:Q96S42

mesoderm formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

negative regulation of androgen receptor signaling pathway

1 reference

8 April 2019

Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

gastrulation with mouth forming second

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

anatomical structure formation involved in morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

Inhibition of Nodal suppresses angiogenesis and growth of human gliomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

regulation of stem cell population maintenance

TAS

1 reference

8 April 2019

Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

formation of anatomical boundary

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

embryonic placenta development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

negative regulation of trophoblast cell migration

1 reference

8 April 2019

Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

tissue morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

BMP signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

embryonic heart tube development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

nodal signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

stem cell population maintenance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

1 reference

8 April 2019

heart looping

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

embryonic process involved in female pregnancy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

heart development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

brain development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

axial mesodermal cell fate specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

vasculature development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of activin receptor signaling pathway

IGI

1 reference

8 April 2019

Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

determination of left/right symmetry

IGI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

maternal placenta development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

regulation of signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

gastrulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

trophectodermal cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Inhibition of Nodal suppresses angiogenesis and growth of human gliomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

embryonic cranial skeleton morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

liver development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of vascular endothelial growth factor production

1 reference

8 April 2019

Inhibition of Nodal suppresses angiogenesis and growth of human gliomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

cell migration involved in gastrulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

negative regulation of chorionic trophoblast cell proliferation

1 reference

8 April 2019

Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

anterior/posterior axis specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

regulation of gastrulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

primitive streak formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

negative regulation of cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

digestive tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of SMAD protein signal transduction

1 reference

8 April 2019

Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

anterior/posterior pattern specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

inhibition of neuroepithelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

cell development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

positive regulation of pathway-restricted SMAD protein phosphorylation

regulation of apoptotic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96S42

Transforming growth factor-beta, C-terminal

has part(s)

1 reference

Transforming growth factor beta, conserved site

1 reference