(Q21124898)

English

Notch receptor 4

mammalian protein found in Homo sapiens

Notch homolog 4
notch 4
neurogenic locus notch homolog protein 4
NOTCH4

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

neurogenic locus Notch 4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

Notch-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

Notch, NODP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

Notch, NOD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein heterodimerization activity

determination method

1 reference

9 May 2019

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

endoplasmic reticulum membrane

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

integral component of plasma membrane

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

extracellular region

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

determination method

1 reference

9 May 2019

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

plasma membrane

determination method

2 references

plasma membrane

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

negative regulation of cell differentiation

determination method

1 reference

9 May 2019

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

endothelial cell morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

negative regulation of endothelial cell differentiation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

morphogenesis of a branching structure

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

transcription, DNA-templated

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99466&geneProductId=UniProtKB:Q99466

determination method

mammary gland development

determination method

1 reference

9 May 2019

Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

positive regulation of transcription of Notch receptor target

determination method

1 reference

9 May 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

branching involved in blood vessel morphogenesis

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

cell fate determination

determination method

1 reference

9 May 2019

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

endothelial cell differentiation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

transcription initiation from RNA polymerase II promoter

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

Notch signaling pathway

determination method

cell differentiation

determination method

3 references

9 May 2019

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

regulation of developmental process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

vasculature development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

determination method

1 reference

9 May 2019

Notch receptors and hematopoiesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

miRNA-mediated gene silencing by inhibition of translation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

positive regulation of Notch signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

negative regulation of Notch signaling pathway

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99466

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

EGF-type aspartate/asparagine hydroxylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

EGF-like calcium-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

Notch, NOD domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

Notch, NODP domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

ankyrin repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99466

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000364163

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000364163

ENSP00000401321

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401321

ENSP00000403447

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403447

ENSP00000408335

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408335

ENSP00000389207

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389207

ENSP00000372751

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000372751

ENSP00000410674

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000410674

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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