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(Q21125466)
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English
Tryptophan hydroxylase 2
mammalian protein found in Homo sapiens
TPH2
tryptophan 5-monooxygenase 2
tryptophan 5-hydroxylase 2
neuronal tryptophan hydroxylase
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8IWU9
part of
Aromatic amino acid monoxygenase, C-terminal domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IWU9
Tryptophan 5-monooxygenase
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IWU9
Aromatic amino acid hydroxylase superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IWU9
Aromatic amino acid hydroxylase, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
ACT domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Aromatic amino acid hydroxylase, iron/copper binding site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8IWU9
encoded by
TPH2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8IWU9
molecular function
iron ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
metal ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IWU9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
monooxygenase activity
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IWU9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
tryptophan 5-monooxygenase activity
determination method
IEA
3 references
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IWU9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU9&geneProductId=UniProtKB:Q8IWU9
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU9&geneProductId=UniProtKB:Q8IWU9
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU9&geneProductId=UniProtKB:Q8IWU9
determination method
IEA
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
oxidoreductase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IWU9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
tryptophan 5-monooxygenase activity
determination method
IBA
IEA
4 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IWU9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IBA
cell component
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
TAS
neuron projection
determination method
IEA
1 reference
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU9&geneProductId=UniProtKB:Q8IWU9
determination method
IEA
neuron projection
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IBA
biological process
cellular response to lithium ion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
response to glucocorticoid
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
response to activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
serotonin biosynthetic process
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IWU9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
response to estrogen
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
response to calcium ion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
aromatic amino acid family metabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
response to nutrient levels
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
circadian rhythm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
IEA
indolalkylamine biosynthetic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU9
determination method
TAS
physically interacts with
fenclonine
has use
enzyme inhibitor
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
5240
language of work or name
English
retrieved
17 August 2016
(RS)-fenfluramine
has use
enzyme inhibitor
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
4613
language of work or name
English
retrieved
17 August 2016
exact match
http://purl.uniprot.org/uniprot/Q8IWU9
1 reference
stated in
Identifiers.org
has part(s)
Aromatic amino acid hydroxylase, iron/copper binding site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IWU9
ACT domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IWU9
Aromatic amino acid hydroxylase, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IWU9
Identifiers
RefSeq protein ID
NP_775489
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
121278
UniProt protein ID
Q8IWU9
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8IWU9
Ensembl protein ID
ENSP00000329093
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000329093
PDB structure ID
4V06
1 reference
stated in
UniProt
UniProt protein ID
Q8IWU9
retrieved
4 August 2016
language of work or name
English
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