Wikidata

(Q21130684)

English

Ubiquitin conjugating enzyme E2 I

mammalian protein found in Homo sapiens

  • SUMO-conjugating enzyme UBC9
  • ubiquitin-protein ligase E2I
  • p18
  • SUMO-1-protein ligase
  • ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
  • RING-type E3 SUMO transferase UBC9
  • ubiquitin carrier protein 9
  • ubiquitin conjugating enzyme E2I
  • ubiquitin conjugating enzyme 9
  • ubiquitin carrier protein I
  • SUMO-protein ligase
  • Ubiquitin-conjugating enzyme E2 I
  • ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
  • ubiquitin-conjugating enzyme UbcE2A
  • ubiquitin-protein ligase I
  • UBE2I
  • ubiquitin-like protein SUMO-1 conjugating enzyme
In more languages

Statements

molecular function
protein binding
determination method
IPI
49 references
retrieved
8 April 2019
stated in
In silico structural and functional characterization of the RSUME splice variants
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3 is stabilized by sumoylation
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
SUMOylation enhances DNA methyltransferase 1 activity
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Bovine papillomavirus E1 protein is sumoylated by the host cell Ubc9 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
A physical interaction network of dengue virus and human proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for the nuclear export activity of Importin13
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
An extended consensus motif enhances the specificity of substrate modification by SUMO
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Sumoylation of the SOX10 transcription factor regulates its transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Sumoylation pathway is required to maintain the basal breast cancer subtype
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Ubc9 interacts with SOX4 and represses its transcriptional activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
retrieved
8 April 2019
stated in
Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
6 references
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IEA
retrieved
17 October 2017
stated in
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic characterization of the human sperm nucleus
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
17 October 2017
stated in
Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IkappaBalpha
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
17 October 2017
stated in
Ubc9 interacts with SOX4 and represses its transcriptional activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IDA
nucleus
determination method
HDA
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IEA
retrieved
8 April 2019
stated in
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
8 April 2019
stated in
Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IkappaBalpha
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
8 April 2019
stated in
Ubc9 interacts with SOX4 and represses its transcriptional activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IBA
retrieved
8 April 2019
stated in
Proteomic characterization of the human sperm nucleus
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
HDA
biological process
protein sumoylation
determination method
IDA
IEA
TAS
6 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
TAS
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IEA
retrieved
17 October 2017
stated in
Ribosomal protein S3 is stabilized by sumoylation
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
17 October 2017
stated in
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
17 October 2017
stated in
SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279
determination method
IDA
protein sumoylation
determination method
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IEA
retrieved
8 April 2019
stated in
Ribosomal protein S3 is stabilized by sumoylation
GOA
curator
UniProt
UniProt protein ID
P63279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
8 April 2019
stated in
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
8 April 2019
stated in
SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279
determination method
IBA

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21130684&oldid=2023013530"