Wikidata

(Q21131023)

English

Microtubule affinity regulating kinase 2

mammalian protein found in Homo sapiens

  • Ser/Thr protein kinase PAR-1B
  • testicular tissue protein Li 117
  • EMK-1
  • serine/threonine protein kinase EMK
  • ELKL motif kinase 1
  • MARK2
  • MAP/microtubule affinity-regulating kinase 2
  • Par-1b
  • serine/threonine-protein kinase MARK2
  • PAR1 homolog b
  • PAR1 homolog
  • Par1b
In more languages

Statements

molecular function
protein serine/threonine kinase activity
determination method
NAS
IDA
TAS
IEA
9 references
retrieved
17 October 2017
stated in
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
TAS
retrieved
17 October 2017
stated in
Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
TAS
retrieved
17 October 2017
stated in
Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
NAS
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
IEA
retrieved
17 October 2017
stated in
Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
IDA
retrieved
17 October 2017
stated in
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
IDA
retrieved
17 October 2017
stated in
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
IDA
retrieved
17 October 2017
stated in
MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KZI7&geneProductId=UniProtKB:Q7KZI7
determination method
IDA
protein binding
determination method
IPI
18 references
retrieved
8 April 2019
stated in
Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
retrieved
8 April 2019
stated in
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IPI
protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
ISS
NAS
TAS
12 references
retrieved
8 April 2019
stated in
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
TAS
retrieved
8 April 2019
stated in
Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
TAS
retrieved
8 April 2019
stated in
Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
NAS
retrieved
8 April 2019
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
NAS
retrieved
8 April 2019
stated in
Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IEA
retrieved
8 April 2019
stated in
MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IDA
retrieved
8 April 2019
stated in
Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IDA
retrieved
8 April 2019
stated in
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IDA
retrieved
8 April 2019
stated in
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
GOA
curator
UniProt
UniProt protein ID
Q7KZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KZI7
determination method
IBA
cell component
biological process

Identifiers

 
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