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Suppressor of cytokine signaling 5
mammalian protein found in Homo sapiens
SOCS5
suppressor of cytokine signaling 5
CIS-6
cytokine-inducible SH2-containing protein 5
cytokine-inducible SH2 protein 6
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O75159
part of
SOCS box-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75159
Suppressor of cytokine signalling 5
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75159
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75159
SOCS5, SOCS box domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS4/SOCS5 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS box domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O75159
encoded by
SOCS5
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O75159
molecular function
epidermal growth factor receptor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
protein kinase inhibitor activity
determination method
IBA
1 reference
retrieved
31 January 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75159&geneProductId=UniProtKB:O75159
determination method
IBA
receptor tyrosine kinase binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IPI
protein binding
determination method
IPI
2 references
retrieved
8 April 2019
stated in
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IPI
1-phosphatidylinositol-3-kinase regulator activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IBA
cell component
cytoplasm
determination method
IBA
1 reference
retrieved
31 January 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75159&geneProductId=UniProtKB:O75159
determination method
IBA
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
TAS
phosphatidylinositol 3-kinase complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IBA
biological process
receptor signaling pathway via JAK-STAT
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
intracellular signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
epidermal growth factor receptor signaling pathway
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
negative regulation of epidermal growth factor-activated receptor activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IDA
cell growth
determination method
NAS
1 reference
retrieved
31 January 2018
stated in
Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75159&geneProductId=UniProtKB:O75159
determination method
NAS
protein ubiquitination
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
regulation of growth
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
determination method
IEA
IMP
2 references
retrieved
8 April 2019
stated in
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
negative regulation of receptor signaling pathway via JAK-STAT
determination method
IBA
1 reference
retrieved
31 January 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75159&geneProductId=UniProtKB:O75159
determination method
IBA
negative regulation of T-helper 2 cell differentiation
determination method
IEA
ISS
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
positive regulation of T-helper 1 cell differentiation
determination method
IEA
ISS
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
negative regulation of signal transduction
determination method
IEA
NAS
2 references
retrieved
8 April 2019
stated in
Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
negative regulation of interleukin-6 production
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
negative regulation of inflammatory response
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
cellular response to low-density lipoprotein particle stimulus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
negative regulation of monocyte chemotactic protein-1 production
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
vascular endothelial cell response to fluid shear stress
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
post-translational protein modification
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
TAS
cytokine-mediated signaling pathway
determination method
IBA
IEA
ISS
TAS
4 references
retrieved
31 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75159&geneProductId=UniProtKB:O75159
determination method
TAS
retrieved
31 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75159&geneProductId=UniProtKB:O75159
determination method
ISS
retrieved
31 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75159&geneProductId=UniProtKB:O75159
determination method
IEA
retrieved
31 January 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75159&geneProductId=UniProtKB:O75159
determination method
IBA
cytokine-mediated signaling pathway
determination method
IEA
ISS
TAS
3 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
regulation of phosphatidylinositol 3-kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IEA
phosphatidylinositol phosphate biosynthetic process
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75159
determination method
IBA
has part(s)
SOCS box domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75159
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75159
SOCS4/SOCS5 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75159
SOCS5, SOCS box domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O75159
Identifiers
RefSeq protein ID
NP_054730
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
9655
NP_659198
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
9655
UniProt protein ID
O75159
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O75159
Ensembl protein ID
ENSP00000305133
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000305133
ENSP00000378330
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000378330
ENSP00000497526
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000497526
PDB structure ID
2N34
1 reference
stated in
Swiss-Prot
UniProt
retrieved
10 November 2015
reference URL
http://www.uniprot.org/uniprot/O54928.txt?version=120
Sitelinks
Wikipedia
(0 entries)
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Wikibooks
(0 entries)
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Wikinews
(0 entries)
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Wikiquote
(0 entries)
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Wikisource
(0 entries)
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Wikiversity
(0 entries)
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Wikivoyage
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Wiktionary
(0 entries)
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Multilingual sites
(0 entries)
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