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(Q21134413)
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English
Syntaxin binding protein 3
mammalian protein found in Homo sapiens
PSP
syntaxin 4 binding protein
STXBP3
unc18-3
protein unc-18 homolog C
syntaxin-binding protein 3
protein unc-18 homolog 3
platelet Sec1 protein
Unc-18C
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O00186
part of
Sec1-like protein
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O00186
Sec1-like superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O00186
Sec1-like, domain 2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O00186
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O00186
encoded by
STXBP3
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O00186
molecular function
syntaxin-1 binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
A role for Sec1/Munc18 proteins in platelet exocytosis
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IPI
syntaxin binding
determination method
IEA
IPI
3 references
retrieved
8 April 2019
stated in
A role for Sec1/Munc18 proteins in platelet exocytosis
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IPI
retrieved
8 April 2019
stated in
Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
platelet alpha granule
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
A role for Sec1/Munc18 proteins in platelet exocytosis
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IDA
cytosol
determination method
IDA
TAS
IEA
4 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
retrieved
8 April 2019
stated in
Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IDA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
tertiary granule
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IDA
plasma membrane
determination method
IDA
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
retrieved
8 April 2019
stated in
Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IDA
basolateral plasma membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
specific granule
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IDA
apical plasma membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
extracellular exosome
determination method
IDA
1 reference
retrieved
26 September 2017
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00186&geneProductId=UniProtKB:O00186
determination method
IDA
phagocytic vesicle
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
extracellular exosome
determination method
HDA
1 reference
retrieved
8 April 2019
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
HDA
presynapse
determination method
EXP
IDA
2 references
retrieved
8 April 2019
stated in
The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons
GOA
curator
SynGO
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IDA
retrieved
8 April 2019
stated in
The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons
GOA
curator
SynGO
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
EXP
biological process
protein to membrane docking
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
protein heterooligomerization
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
neutrophil degranulation
determination method
IEP
1 reference
retrieved
8 April 2019
stated in
Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEP
insulin secretion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
vesicle docking involved in exocytosis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
response to insulin
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
brain development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
negative regulation of calcium ion-dependent exocytosis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Munc18-syntaxin complexes and exocytosis in human platelets
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IMP
protein transport
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
platelet aggregation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
A role for Sec1/Munc18 proteins in platelet exocytosis
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IMP
vesicle-mediated transport
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
exocytosis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
transport
determination method
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
O00186
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00186&geneProductId=UniProtKB:O00186
determination method
IEA
cellular glucose homeostasis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
negative regulation of glucose import
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
cellular response to interferon-gamma
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00186
determination method
IEA
Identifiers
RefSeq protein ID
NP_009200
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6814
UniProt protein ID
O00186
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O00186
Ensembl protein ID
ENSP00000359025
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000359025
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