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Sphingomyelin phosphodiesterase 2
mammalian protein found in Homo sapiens
SMPD2
N-SMase
lyso-PAF-PLC
neutral sphingomyelinase
sphingomyelin phosphodiesterase 2
lyso-platelet-activating factor-phospholipase C
nSMase
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O60906
part of
Endonuclease/exonuclease/phosphatase superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O60906
Sphingomyelin phosphodiesterase 2-like
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O60906
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
Endonuclease/exonuclease/phosphatase family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O60906
encoded by
SMPD2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O60906
molecular function
sphingomyelin phosphodiesterase activity
determination method
IEA
TAS
3 references
retrieved
24 April 2018
stated in
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60906&geneProductId=UniProtKB:O60906
determination method
TAS
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O60906
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60906&geneProductId=UniProtKB:O60906
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60906&geneProductId=UniProtKB:O60906
determination method
IEA
metal ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60906
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
hydrolase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60906
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
sphingomyelin phosphodiesterase activity
determination method
IBA
IEA
TAS
4 references
retrieved
8 April 2019
stated in
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60906
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IBA
cell component
integral component of membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60906
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
membrane
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60906
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
plasma membrane
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
TAS
integral component of plasma membrane
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
TAS
intracellular anatomical structure
determination method
IEA
1 reference
retrieved
10 September 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60906&geneProductId=UniProtKB:O60906
determination method
IEA
caveola
determination method
IEA
1 reference
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60906&geneProductId=UniProtKB:O60906
determination method
IEA
caveola
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IBA
biological process
positive regulation of ceramide biosynthetic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
TAS
intracellular signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
lipid metabolism
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60906
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
ceramide biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
response to mechanical stimulus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
sphingomyelin metabolic process
determination method
TAS
1 reference
retrieved
10 September 2018
stated in
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60906&geneProductId=UniProtKB:O60906
determination method
TAS
sphingolipid metabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60906
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
sphingomyelin metabolic process
determination method
IBA
TAS
2 references
retrieved
8 April 2019
stated in
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
TAS
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IBA
sphingomyelin catabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
IEA
glycosphingolipid metabolic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60906
determination method
TAS
has part(s)
Endonuclease/exonuclease/phosphatase
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O60906
Identifiers
RefSeq protein ID
NP_003071
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6610
XP_005267166
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6610
XP_011534381
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6610
XP_024302294
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6610
XP_024302295
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6610
UniProt protein ID
O60906
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O60906
Ensembl protein ID
ENSP00000258052
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000258052
ENSP00000399731
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000399731
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