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Insulin receptor substrate 4
mammalian protein found in Homo sapiens
160 kDa phosphotyrosine protein
insulin receptor substrate 4
phosphoprotein of 160 kDa
IRS4
py160
pp160
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14654
part of
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14654
encoded by
IRS4
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14654
molecular function
phosphatidylinositol 3-kinase binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IBA
protein binding
determination method
IPI
3 references
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IPI
retrieved
8 April 2019
stated in
The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IPI
signal transducer activity
determination method
IBA
IEA
TAS
4 references
retrieved
27 March 2018
stated in
Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14654&geneProductId=UniProtKB:O14654
determination method
TAS
retrieved
27 March 2018
stated in
A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14654&geneProductId=UniProtKB:O14654
determination method
TAS
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O14654
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14654&geneProductId=UniProtKB:O14654
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14654&geneProductId=UniProtKB:O14654
determination method
IBA
insulin receptor binding
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14654&geneProductId=UniProtKB:O14654
determination method
IBA
insulin receptor binding
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IBA
cell component
cytosol
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IBA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14654
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IEA
plasma membrane
determination method
IBA
IEA
TAS
4 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
TAS
retrieved
8 April 2019
stated in
Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14654
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IBA
biological process
insulin receptor signaling pathway
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14654&geneProductId=UniProtKB:O14654
determination method
IBA
regulation of lipid metabolic process
determination method
IBA
1 reference
retrieved
21 June 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14654&geneProductId=UniProtKB:O14654
determination method
IBA
signal transduction
determination method
TAS
IEA
2 references
retrieved
8 April 2019
stated in
A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14654
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IEA
positive regulation of signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IEA
insulin receptor signaling pathway
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14654
determination method
IBA
Identifiers
RefSeq protein ID
NP_003595
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
8471
XP_006724776
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
8471
XP_011529363
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
8471
NP_001366079
1 reference
stated in
NCBI Gene
retrieved
4 April 2020
Entrez Gene ID
8471
UniProt protein ID
O14654
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14654
Ensembl protein ID
ENSP00000361202
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000361202
ENSP00000457111
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000457111
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