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(Q21172741)
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G protein-coupled receptor 3
mammalian protein found in Homo sapiens
G-protein coupled receptor 3
GPR3
adenylate cyclase constitutive activator
ACCA orphan receptor
In more languages
default values for all languages
No label defined
No description defined
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P46089
part of
G protein-coupled receptor 3
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P46089
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
GPCR, rhodopsin-like, 7TM, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P46089
encoded by
GPR3
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P46089
molecular function
G protein-coupled receptor activity
determination method
IEA
TAS
3 references
retrieved
8 April 2019
stated in
Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46089
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IPI
signal transducer activity
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P46089
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P46089&geneProductId=UniProtKB:P46089
determination method
IEA
cell component
integral component of membrane
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46089
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
plasma membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46089
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
integral component of plasma membrane
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
TAS
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46089
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
intracellular anatomical structure
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P46089&geneProductId=UniProtKB:P46089
determination method
IEA
biological process
G protein-coupled receptor signaling pathway
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46089
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
regulation of meiotic nuclear division
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
adenylate cyclase-activating G protein-coupled receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
TAS
signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46089
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
positive regulation of cold-induced thermogenesis
determination method
IEA
ISS
2 references
retrieved
8 April 2019
stated in
Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue
GOA
curator
YuBioLab
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46089
determination method
IEA
physically interacts with
sphingosine 1-phosphate
has use
agonist
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
911
language of work or name
English
retrieved
17 August 2016
has part(s)
GPCR, rhodopsin-like, 7TM
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P46089
Identifiers
RefSeq protein ID
NP_005272
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2827
UniProt protein ID
P46089
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P46089
Ensembl protein ID
ENSP00000363136
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000363136
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