(Q21172915)

English

Drebrin 1

mammalian protein found in Homo sapiens

drebrin E2
drebrin
drebrin A
developmentally-regulated brain protein
drebrin E
DBN1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

ADF-H/Gelsolin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16643

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16643

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Actin-depolymerising factor homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

profilin binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

protein binding

determination method

10 references

8 April 2019

The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

Actin-binding protein drebrin regulates HIV-1-triggered actin polymerization and viral infection

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

Phospho-tyrosine dependent protein-protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

A novel role for drebrin in regulating progranulin bioactivity in bladder cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

4 references

8 April 2019

Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

cadherin binding

determination method

1 reference

14 February 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q16643

determination method

cadherin binding

determination method

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

cell-cell junction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

intracellular anatomical structure

determination method

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q16643

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

1 reference

14 February 2017

Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q16643

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

1 reference

8 April 2019

Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

plasma membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

actin cytoskeleton

determination method

3 references

determination method

4 references

8 April 2019

Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

1 reference

8 April 2019

Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

postsynaptic density

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

cortical cytoskeleton

determination method

1 reference

8 April 2019

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

postsynaptic membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

postsynaptic cytosol

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

determination method

3 references

8 April 2019

Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

8 April 2019

Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

biological process

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

cell communication by electrical coupling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

regulation of dendrite development

determination method

1 reference

8 April 2019

Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

nervous system development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

generation of neurons

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

neural precursor cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

regulation of neuronal synaptic plasticity

determination method

1 reference

8 April 2019

Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

maintenance of protein location in cell

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

cell communication by chemical coupling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

actin filament organization

determination method

cytoplasmic sequestering of protein

determination method

1 reference

8 April 2019

The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16643

determination method

Actin-depolymerising factor homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16643

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000292385

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000292385

ENSP00000308532

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000308532

ENSP00000377195

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377195

ENSP00000421465

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421465

ENSP00000422854

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422854

ENSP00000423208

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423208

ENSP00000425546

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425546

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