Wikidata

(Q21173409)

English

Mediator complex subunit 1

mammalian protein found in Homo sapiens

  • MED1
  • activator-recruited cofactor 205 kDa component
  • vitamin D receptor-interacting protein complex component DRIP205
  • Trap220
  • p53 regulatory protein RB18A
  • TR-interacting protein 2
  • Thyroid receptor-interacting protein 2
  • thyroid receptor interacting protein 2
  • mediator of RNA polymerase II transcription subunit 1
  • PBP
  • peroxisome proliferator-activated receptor-binding protein
  • thyroid hormone receptor-associated protein complex component TRAP220
  • vitamin D receptor-interacting protein 230 kD
  • PPAR-binding protein
  • ARC205
  • TRIP-2
  • PPARG binding protein
  • thyroid hormone receptor-associated protein complex 220 kDa component
In more languages

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
Enhancer activation requires trans-recruitment of a mega transcription factor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
Subunit architecture and functional modular rearrangements of the transcriptional mediator complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
retrieved
8 April 2019
stated in
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IPI
transcription coactivator activity
determination method
IDA
IEA
IMP
TAS
8 references
retrieved
8 April 2019
stated in
Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
TAS
retrieved
8 April 2019
stated in
Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IMP
retrieved
8 April 2019
stated in
CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IEA
retrieved
8 April 2019
stated in
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
cell component
nucleus
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IEA
retrieved
8 April 2019
stated in
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
Composite co-activator ARC mediates chromatin-directed transcriptional activation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
mediator complex
determination method
IDA
IEA
IMP
6 references
retrieved
17 October 2017
stated in
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
determination method
IEA
retrieved
17 October 2017
stated in
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
17 October 2017
stated in
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
17 October 2017
stated in
A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
determination method
IDA
mediator complex
determination method
IBA
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IEA
retrieved
8 April 2019
stated in
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IMP
retrieved
8 April 2019
stated in
Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IEA
retrieved
8 April 2019
stated in
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation
GOA
curator
UniProt
UniProt protein ID
Q15648
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA
retrieved
8 April 2019
stated in
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
determination method
IDA

Identifiers

PDB structure ID
 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21173409&oldid=2091138309"