(Q21173835)

English

Sphingosine kinase 2

mammalian protein found in Homo sapiens

SPHK2
sphingosine kinase type 2
sphingosine kinase 2

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRA0

NAD kinase/diacylglycerol kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRA0

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Diacylglycerol kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

sphingosine-1-phosphate receptor activity

determination method

1 reference

8 April 2019

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

protein binding

determination method

3 references

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

sphinganine kinase activity

determination method

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NRA0&geneProductId=UniProtKB:Q9NRA0

determination method

1 January 2018

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NRA0&geneProductId=UniProtKB:Q9NRA0

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NRA0&geneProductId=UniProtKB:Q9NRA0

determination method

NAD+ kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

D-erythro-sphingosine kinase activity

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

sphinganine kinase activity

determination method

3 references

8 April 2019

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

1 reference

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

mitochondrial inner membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

biological process

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

sphinganine-1-phosphate biosynthetic process

determination method

1 reference

1 January 2018

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

female pregnancy

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

sphingosine metabolic process

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

sphingosine biosynthetic process

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

sphingolipid biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

brain development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

blood vessel development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

lipid phosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

sphingosine-1-phosphate receptor signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NRA0&geneProductId=UniProtKB:Q9NRA0

determination method

sphinganine-1-phosphate biosynthetic process

determination method

4 references

8 April 2019

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

8 April 2019

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

negative regulation of histone deacetylation

determination method

1 reference

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

histone H2A-K5 acetylation

determination method

1 reference

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

histone H2B-K12 acetylation

determination method

1 reference

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

epigenetic maintenance of chromatin in transcription-competent conformation

determination method

1 reference

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

negative regulation of histone deacetylase activity

determination method

1 reference

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

cellular response to phorbol 13-acetate 12-myristate

determination method

1 reference

8 April 2019

Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

positive regulation of histone H3-K9 acetylation

determination method

1 reference

8 April 2019

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRA0

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2158685

Diacylglycerol kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRA0

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000245222

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000245222

ENSP00000469158

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469158

ENSP00000470092

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470092

ENSP00000471205

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471205

ENSP00000341091

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000341091

ENSP00000410044

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000410044

ENSP00000469448

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469448

ENSP00000470679

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470679

ENSP00000471111

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471111

ENSP00000471180

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471180

ENSP00000472983

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472983

Sitelinks

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Multilingual sites(0 entries)

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