(Q21174672)

English

NADH:ubiquinone oxidoreductase subunit A1

mammalian protein found in Homo sapiens

CI-MWFE
NADH:ubiquinone oxidoreductase (complex 1)
type I dehydrogenase
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
complex I MWFE subunit
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
NADH-ubiquinone oxidoreductase MWFE subunit
NADH oxidoreductase subunit MWFE
complex I-MWFE
NDUFA1

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Statements

1 reference

13 November 2019

NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15239

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

13 November 2019

1 reference

13 November 2019

NADH dehydrogenase (ubiquinone) activity

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

3 references

mitochondrial respiratory chain complex I

4 references

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

8 April 2019

Accessory subunits are integral for assembly and function of human mitochondrial complex I.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

8 April 2019

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

8 April 2019

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method

IEA

mitochondrial membranes

1 reference

8 April 2019

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15239

determination method

IDA

biological process

mitochondrial electron transport, NADH to ubiquinone

1 reference

1 January 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15239&geneProductId=UniProtKB:O15239

determination method

NAS

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1431

metformin hydrochloride

object has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1703

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

(Q21174672)

NADH:ubiquinone oxidoreductase subunit A1

Statements

Identifiers

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