(Q21204094)

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.16.1

2 October 2019

hierarchical database ID heuristic

membrane protein

1 reference

inferred from GOA cell component → membrane

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

Frizzled domain, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

frizzled binding

1 reference

1 January 2018

Myocilin is a modulator of Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

1 reference

17 October 2017

Wnt-protein binding

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

protein binding

1 reference

1 January 2018

Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

Wnt-activated receptor activity

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

17 October 2017

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

signaling receptor binding

1 reference

1 January 2018

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

Wnt-protein binding

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

Wnt-activated receptor activity

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

cell component

Wnt signalosome

IC

1 reference

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

IC

focal adhesion

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

cell surface

1 reference

1 January 2018

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

integral component of membrane

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

focal adhesion

HDA

1 reference

1 January 2018

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

G protein-coupled receptor signaling pathway

HDA

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

positive regulation of protein phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

autocrine signaling

1 reference

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

epithelial cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

muscular septum morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

ventricular septum morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

membranous septum morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

outflow tract morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

positive regulation of DNA-binding transcription factor activity

planar cell polarity pathway involved in neural tube closure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

negative regulation of BMP signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

positive regulation of transcription, DNA-templated

1 reference

1 January 2018

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

cell surface receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation

1 reference

1 January 2018

Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

canonical Wnt signaling pathway involved in osteoblast differentiation

1 reference

1 January 2018

Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

hard palate development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

canonical Wnt signaling pathway

ISS

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

6 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

17 October 2017

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

negative regulation of transcription, DNA-templated

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

1 reference

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

beta-catenin destruction complex disassembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

Wnt signaling pathway, planar cell polarity pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

presynapse assembly

1 reference

1 January 2018

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

negative regulation of oxidative stress-induced neuron death

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

non-canonical Wnt signaling pathway

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

positive regulation of neuron projection development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

1 January 2018

canonical Wnt signaling pathway

ISS

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

negative regulation of canonical Wnt signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

regulation of presynapse assembly

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

1 reference

GPCR, family 2-like

1 reference

Frizzled/Smoothened, transmembrane domain

1 reference

Transporter Classification Database ID

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

9.A.14.16.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database