(Q21495343)

Metallopeptidase, catalytic domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Peptidase M12B, ADAM/reprolysin, protein family

1 reference

Reprolysin domain, adamalysin-type, protein family

1 reference

ADAM, cysteine-rich, protein family

1 reference

Disintegrin domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Disintegrin, conserved site, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Peptidase M12B, propeptide family

1 reference

The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

Regulation of osteoclast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

3 references

14 February 2019

The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

metalloendopeptidase activity

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

metallopeptidase activity

IEA

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

cell adhesion molecule binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex

IEA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

integral component of plasma membrane

alpha9-beta1 integrin-ADAM8 complex

1 reference

14 February 2019

Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

dense core granule membrane

4 references

14 February 2019

ADAM8: a new therapeutic target for asthma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

negative regulation of neuron apoptotic process

1 reference

14 February 2019

Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of protein kinase B signaling

1 reference

14 February 2019

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of T cell differentiation in thymus

1 reference

14 February 2019

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of inflammatory response

1 reference

14 February 2019

ADAM8: a new therapeutic target for asthma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

1 reference

14 February 2019

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

blood vessel endothelial cell migration

1 reference

14 February 2019

ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of membrane protein ectodomain proteolysis

NAS

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

14 February 2019

Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

leukocyte migration involved in inflammatory response

1 reference

14 February 2019

The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

ADAM8: a novel osteoclast stimulating factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

ADAM8: a novel osteoclast stimulating factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

2 references

positive regulation of cellular extravasation

1 reference

14 February 2019

The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of eosinophil migration

1 reference

14 February 2019

The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

regulation of osteoclast differentiation

TAS

1 reference

14 February 2019

Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of NF-kappaB transcription factor activity

NAS

1 reference

14 February 2019

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

regulation of cell-cell adhesion

positive regulation of fibronectin-dependent thymocyte migration

1 reference

14 February 2019

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of acute inflammatory response

1 reference

14 February 2019

ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity

lymphocyte chemotaxis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of thymocyte apoptotic process

1 reference

14 February 2019

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

ADAM8: a novel osteoclast stimulating factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

cellular response to hypoxia

TAS

positive regulation of T cell migration

1 reference

14 February 2019

The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

negative regulation of thymocyte aggregation

1 reference

14 February 2019

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of cell adhesion

NAS

1 reference

14 February 2019

The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

1 reference

14 February 2019

The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of MAP kinase activity

1 reference

14 February 2019

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

positive regulation of innate immune response

1 reference

14 February 2019

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05910

Peptidase M12B, propeptide

has part(s)

1 reference

ADAM, cysteine-rich

1 reference

EGF-like, conserved site

1 reference

EGF-like domain

1 reference

Peptidase M12B, ADAM/reprolysin

1 reference

Disintegrin domain

1 reference

Disintegrin, conserved site

1 reference

Reprolysin domain, adamalysin-type

1 reference