(Q21495558)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88974

Histone-lysine N-methyltransferase SETDB1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88974

Tudor domain, protein family

1 reference

Post-SET domain, protein family

1 reference

SET domain, protein family

1 reference

Pre-SET domain, protein family

1 reference

Methyl-CpG DNA binding domain, protein family

1 reference

methyltransferase activity

1 reference

10 August 2016

language of work or name

1 reference

10 August 2016

language of work or name

English

molecular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

1 reference

14 February 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

1 reference

14 February 2019

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

1 reference

14 February 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

1 reference

14 February 2019

chromatin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

protein binding

histone-lysine N-methyltransferase activity

IPI

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88974&geneProductId=UniProtKB:O88974

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88974&geneProductId=UniProtKB:O88974

1 January 2018

1 January 2018

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88974&geneProductId=UniProtKB:O88974

histone methyltransferase activity (H3-K9 specific)

1 reference

1 January 2018

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88974&geneProductId=UniProtKB:O88974

promoter-specific chromatin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

histone-lysine N-methyltransferase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

14 February 2019

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

histone methyltransferase activity (H3-K9 specific)

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

intracellular membrane-bounded organelle

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

nucleoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

1 reference

14 February 2019

nucleus

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

14 February 2019

Histone H3-K9 methyltransferase ESET is essential for early development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88974&geneProductId=UniProtKB:O88974

1 reference

1 January 2018

regulation of transcription, DNA-templated

ISS

biological process

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88974&geneProductId=UniProtKB:O88974

1 reference

27 February 2018

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88974&geneProductId=UniProtKB:O88974

1 reference

27 February 2018

histone H3-K9 trimethylation

1 reference

14 February 2019

Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

inner cell mass cell proliferation

1 reference

14 February 2019

Histone H3-K9 methyltransferase ESET is essential for early development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

1 reference

14 February 2019

histone lysine methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

1 reference

14 February 2019

bone development

1 reference

14 February 2019

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

chromatin organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

1 reference

14 February 2019

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA methylation-dependent heterochromatin assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974

14 February 2019

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88974