(Q21495561)

http://www.ebi.ac.uk/interpro/protein/P25118

Death-like domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25118

membrane proteins

1 reference

inferred from GOA cell component → membrane

Tumor necrosis factor receptor 1A, N-terminal domain, protein family

1 reference

Tumor necrosis factor receptor 1A, death domain, protein family

1 reference

Death domain, protein family

1 reference

TNFR/NGFR cysteine-rich region, protein family

1 reference

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

1 reference

25 May 2022

1 reference

25 May 2022

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Hepatitis C virus core protein potentiates TNF-alpha-induced NF-kappaB activation through TRAF2-IKKbeta-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

tumor necrosis factor-activated receptor activity

6 references

16 July 2018

The locus of tumor necrosis factor-alpha action in lung inflammation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

tumor necrosis factor-activated receptor activity

7 references

14 February 2019

TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

The locus of tumor necrosis factor-alpha action in lung inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

tumor necrosis factor binding

3 references

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

integral component of plasma membrane

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

The shedding activity of ADAM17 is sequestered in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

3 references

14 February 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

The shedding activity of ADAM17 is sequestered in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

14 February 2019

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

positive regulation of inflammatory response

cytokine-mediated signaling pathway

1 reference

14 February 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

tumor necrosis factor-mediated signaling pathway

multicellular organism development

3 references

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

cell surface receptor signaling pathway

1 reference

14 February 2019

TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

response to lipopolysaccharide

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

cellular response to mechanical stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

regulation of cell population proliferation

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

defense response to bacterium

1 reference

14 February 2019

Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

The locus of tumor necrosis factor-alpha action in lung inflammation

inflammatory response

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25118&geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

positive regulation of transcription by RNA polymerase II

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

negative regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

negative regulation of interleukin-6 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

negative regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

positive regulation of neuron apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

positive regulation of angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

protein heterooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

aortic valve development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

pulmonary valve development

1 reference

14 February 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

negative regulation of extracellular matrix constituent secretion

1 reference

14 February 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

negative regulation of cardiac muscle hypertrophy

1 reference

14 February 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

positive regulation of apoptotic process involved in morphogenesis

1 reference

14 February 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation

inflammatory response

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

The locus of tumor necrosis factor-alpha action in lung inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118

regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25118