(Q21495768)

http://www.ebi.ac.uk/interpro/protein/P18052

Receptor tyrosine-protein phosphatase alpha

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18052

membrane proteins

1 reference

inferred from GOA cell component → membrane

Tyrosine specific protein phosphatases domain, protein family

1 reference

PTP type protein phosphatase domain, protein family

1 reference

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

Protein-tyrosine phosphatase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

phosphoprotein phosphatase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

7 references

9 May 2019

The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase alpha is required for Src activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

protein tyrosine phosphatase activity

IPI

identical protein binding

3 references

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18052&geneProductId=UniProtKB:P18052

protein-containing complex binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

protein tyrosine phosphatase activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

integral component of membrane

IBA

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

intracellular membrane-bounded organelle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

Schaffer collateral - CA1 synapse

1 reference

9 May 2019

Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

integral component of synaptic membrane

IMP

1 reference

9 May 2019

Reduced NMDA receptor tyrosine phosphorylation in PTPalpha-deficient mouse synaptosomes is accompanied by inhibition of four src family kinases and Pyk2: an upstream role for PTPalpha in NMDA receptor regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha

IDA

biological process

protein phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

insulin receptor signaling pathway

IDA

1 reference

9 May 2019

Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

protein dephosphorylation

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

peptidyl-tyrosine dephosphorylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

positive regulation of oligodendrocyte differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052

modulation of chemical synaptic transmission

1 reference

9 May 2019

Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18052