(Q21495924)

http://www.ebi.ac.uk/interpro/protein/Q91VN0

LDL receptor-like superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q91VN0

Six-bladed beta-propeller, TolB-like

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q91VN0

membrane protein

1 reference

inferred from GOA cell component → membrane

EGF-like domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

LDLR class B repeat, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

4 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

Wnt-activated receptor activity

3 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

14 January 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

14 January 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

coreceptor activity involved in Wnt signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

Wnt-activated receptor activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

integral component of membrane

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

endoplasmic reticulum

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

1 reference

16 September 2017

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

1 reference

9 May 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

regulation of apoptotic process

HDA

biological process

1 reference

9 May 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

positive regulation of osteoblast proliferation

1 reference

9 May 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

16 September 2017

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

1 reference

9 May 2019

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

extracellular matrix-cell signaling

1 reference

9 May 2019

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

branching involved in mammary gland duct morphogenesis

1 reference

16 September 2017

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

somatic stem cell population maintenance

1 reference

9 May 2019

The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

gastrulation with mouth forming second

bone marrow development

1 reference

16 September 2017

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

embryonic digit morphogenesis

1 reference

9 May 2019

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

positive regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

cell-cell signaling involved in mammary gland development

1 reference

9 May 2019

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

cholesterol metabolic process

1 reference

9 May 2019

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

Wnt signaling pathway

5 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

anatomical structure regression

1 reference

9 May 2019

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

mammary gland duct morphogenesis

1 reference

9 May 2019

The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

positive regulation of transcription, DNA-templated

3 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

positive regulation of skeletal muscle acetylcholine-gated channel clustering

1 reference

9 May 2019

LRP4 serves as a coreceptor of agrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

vasculature development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

apoptotic process involved in blood vessel morphogenesis

1 reference

9 May 2019

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

7 references

16 September 2017

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Bone biomechanical properties in LRP5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Gender specific LRP5 influences on trabecular bone structure and strength

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

PTH stimulates bone formation in mice deficient in Lrp5

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

Wnt signaling pathway involved in dorsal/ventral axis specification

retinal blood vessel morphogenesis

canonical Wnt signaling pathway

6 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

16 September 2017

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

osteoblast development

adipose tissue development

2 references

cell migration involved in gastrulation

1 reference

9 May 2019

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone

cholesterol homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

retina vasculature morphogenesis in camera-type eye

3 references

9 May 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

A model for familial exudative vitreoretinopathy caused by LPR5 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

anterior/posterior pattern specification

1 reference

16 September 2017

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91VN0&geneProductId=UniProtKB:Q91VN0

regulation of bone remodeling

1 reference

14 February 2019

High bone mass in mice expressing a mutant LRP5 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

response to peptide hormone

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

response to radiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

positive regulation of mesenchymal cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

osteoblast development

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

glucose catabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

regulation of blood pressure

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

positive regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

positive regulation of fat cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

negative regulation of osteoblast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

positive regulation of osteoblast differentiation

1 reference

9 May 2019

MiR-9-5p, miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation, Differentiation, and Adhesion.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

positive regulation of mitotic nuclear division

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 references

9 May 2019

Bone biomechanical properties in LRP5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Gender specific LRP5 influences on trabecular bone structure and strength

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

High bone mass in mice expressing a mutant LRP5 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

PTH stimulates bone formation in mice deficient in Lrp5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

retina morphogenesis in camera-type eye

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

canonical Wnt signaling pathway

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein serine/threonine kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

Norrin signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91VN0

Wnt signaling pathway

1 reference

9 May 2019