(Q21496043)

http://www.ebi.ac.uk/interpro/protein/Q02152

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

GTPase activator activity

1 reference

14 February 2019

Ras involvement in signal transduction by the serotonin 5-HT2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

G protein-coupled serotonin receptor activity

5 references

16 July 2018

Serotonin 2B receptor is required for heart development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

16 July 2018

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

16 July 2018

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

G-protein alpha-subunit binding

3 references

3 references

14 February 2019

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

neurotransmitter receptor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

G protein-coupled receptor activity

G protein-coupled serotonin receptor activity

6 references

14 February 2019

Serotonin 2B receptor is required for heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

integral component of membrane

2 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

integral component of plasma membrane

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

2 references

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

intestine smooth muscle contraction

biological process

3 references

smooth muscle contraction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

G protein-coupled receptor internalization

1 reference

14 February 2019

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

G protein-coupled receptor signaling pathway

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

regulation of behavior

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

A population-specific HTR2B stop codon predisposes to severe impulsivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

positive regulation of endothelial cell proliferation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

phospholipase C-activating serotonin receptor signaling pathway

1 reference

14 February 2019

Serotonin 2B receptor is required for heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

positive regulation of cytokine production

TAS

3 references

3 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

ERK1 and ERK2 cascade

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

Ras involvement in signal transduction by the serotonin 5-HT2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

positive regulation of phosphatidylinositol biosynthetic process

3 references

cardiac muscle hypertrophy

1 reference

14 February 2019

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

1 reference

14 February 2019

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

neural crest cell differentiation

1 reference

14 February 2019

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

negative regulation of apoptotic process

1 reference

14 February 2019

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

negative regulation of cell death

3 references

protein kinase C signaling

3 references

cGMP biosynthetic process

cellular response to temperature stimulus

1 reference

14 February 2019

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

positive regulation of nitric-oxide synthase activity

3 references

protein kinase C-activating G protein-coupled receptor signaling pathway

1 reference

14 February 2019

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells

embryonic morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

serotonin receptor signaling pathway

3 references

neural crest cell migration

1 reference

14 February 2019

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

positive regulation of cell population proliferation

3 references

phosphatidylinositol 3-kinase signaling

3 references

negative regulation of autophagy

3 references

positive regulation of cell division

1 reference

14 February 2019

Ras involvement in signal transduction by the serotonin 5-HT2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

calcium-mediated signaling

3 references

release of sequestered calcium ion into cytosol

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

positive regulation of GTPase activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

ion transmembrane transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

cellular response to amine stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

cellular response to serotonin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

cGMP biosynthetic process

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02152&geneProductId=UniProtKB:Q02152

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

cGMP-mediated signaling

3 references

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

chemical synaptic transmission

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02152

release of sequestered calcium ion into cytosol

3 references

GPCR, rhodopsin-like, 7TM

1 reference

stated in

InterPro Release 71.0