(Q21496052)

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

inferred from protein domain or family

HD/PDEase domain, protein family

1 reference

inferred from protein domain or family

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

3',5'-cyclic-nucleotide phosphodiesterase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

transmembrane transporter binding

3 references

10 September 2018

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

10 September 2018

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

scaffold protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

phosphoric diester hydrolase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

3',5'-cyclic-AMP phosphodiesterase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

3 references

14 February 2019

DISC1, PDE4B, and NDE1 at the centrosome and synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

transmembrane transporter binding

IBA

4 references

14 February 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

3 references

14 February 2019

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

voltage-gated calcium channel complex

1 reference

14 February 2019

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

10 September 2018

DISC1, PDE4B, and NDE1 at the centrosome and synapse

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

2 references

microtubule organizing center

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

apical plasma membrane

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

establishment of endothelial barrier

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

smooth muscle contraction

ISS

1 reference

14 February 2019

PDE4D plays a critical role in the control of airway smooth muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

regulation of ryanodine-sensitive calcium-release channel activity

1 reference

14 February 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

PDE4D plays a critical role in the control of airway smooth muscle contraction

cAMP catabolic process

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

27 March 2018

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

positive regulation of interleukin-5 production

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

multicellular organism growth

1 reference

14 February 2019

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

negative regulation of heart contraction

1 reference

14 February 2019

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

positive regulation of interferon-gamma production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation

neutrophil chemotaxis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

regulation of heart rate

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

regulation of cardiac muscle cell contraction

2 references

10 September 2018

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

10 September 2018

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

positive regulation of interleukin-2 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

negative regulation of peptidyl-serine phosphorylation

1 reference

14 February 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

regulation of cell communication by electrical coupling involved in cardiac conduction

1 reference

14 February 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

cellular response to lipopolysaccharide

IC

1 reference

14 February 2019

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

T cell receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

1 reference

14 February 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

negative regulation of relaxation of cardiac muscle

1 reference

14 February 2019

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

cellular response to epinephrine stimulus

1 reference

14 February 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

cAMP catabolic process

1 reference

10 September 2018

negative regulation of cAMP-mediated signaling

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01063&geneProductId=UniProtKB:Q01063

regulation of cardiac muscle cell contraction

3 references

14 February 2019

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01063

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IBA

has part(s)

1 reference

3'5'-cyclic nucleotide phosphodiesterase, conserved site

1 reference

HD/PDEase domain

1 reference