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Rho guanine nucleotide exchange factor (GEF) 12
mammalian protein found in Mus musculus
leukemia-associated RhoGEF
leukemia-associated Rho guanine-nucleotide exchange factor
rho guanine nucleotide exchange factor 12
Arhgef12
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
Q8R4H2
part of
Dbl homology (DH) domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
RGS domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
PDZ superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
pleckstrin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Regulator of G protein signalling-like domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
LARG, RGS domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
ARHGEF12, PH domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
PDZ domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Dbl homology (DH) domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Guanine-nucleotide dissociation stimulator, CDC24, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
Q8R4H2
encoded by
Arhgef12
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
Q8R4H2
molecular function
protein binding
determination method
IPI
2 references
retrieved
14 February 2019
stated in
Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IPI
retrieved
14 February 2019
stated in
Suppression of bone formation by osteoclastic expression of semaphorin 4D
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IPI
GTPase activator activity
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4H2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
guanyl-nucleotide exchange factor activity
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4H2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
G protein-coupled receptor binding
determination method
IEA
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
cell component
cytoplasm
determination method
IEA
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4H2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8R4H2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
biological process
positive regulation of GTPase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
regulation of Rho protein signal transduction
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
intracellular signal transduction
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
G protein-coupled receptor signaling pathway
determination method
IEA
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
Rho protein signal transduction
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R4H2
determination method
IEA
has part(s)
PDZ domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
Guanine-nucleotide dissociation stimulator, CDC24, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
pleckstrin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
Dbl homology (DH) domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
Regulator of G protein signalling-like domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
ARHGEF12, PH domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
LARG, RGS domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8R4H2
Identifiers
RefSeq protein ID
NP_081420
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_011240899
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_011240900
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_017169054
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_017169055
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_017169056
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
NP_001346161
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_030100431
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_030100432
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_030100433
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_036011146
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
XP_036011147
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
69632
UniProt protein ID
Q8R4H2
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
Q8R4H2
Ensembl protein ID
ENSMUSP00000072547
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000072547
ENSMUSP00000126598
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000126598
ENSMUSP00000150833
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000150833
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Multilingual sites
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