(Q21496326)

Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily

1 reference

Tyramine beta-hydroxylase/Dopamine beta-hydroxylase

1 reference

Copper type II, ascorbate-dependent monooxygenase-like, C-terminal

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Copper type II, ascorbate-dependent monooxygenase, N-terminal domain, protein family

1 reference

DOMON domain, protein family

1 reference

Copper type II ascorbate-dependent monooxygenase, C-terminal domain, protein family

1 reference

Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site, protein family

1 reference

Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

L-ascorbic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

1 reference

24 April 2018

catalytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

dopamine beta-monooxygenase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

copper ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

2 references

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

transport vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

chromaffin granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

chromaffin granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

secretory granule membrane

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

IDA

secretory granule lumen

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

IDA

cytoplasm

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

axon

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

dendrite

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

neuronal cell body

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

terminal bouton

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

varicosity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

apical part of cell

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

secretory granule membrane

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

IDA

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

biological process

visual learning

1 reference

14 February 2019

Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

fear response

1 reference

14 February 2019

A distinct role for norepinephrine in memory retrieval

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

associative learning

1 reference

14 February 2019

Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

homoiothermy

1 reference

14 February 2019

Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

regulation of extrinsic apoptotic signaling pathway

1 reference

14 February 2019

Adrenergic catecholamine trophic activity contributes to flow-mediated arterial remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

locomotory behavior

response to amphetamine

1 reference

14 February 2019

Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

cytokine production

1 reference

14 February 2019

Dopamine beta-hydroxylase deficiency impairs cellular immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

catecholamine biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

1 reference

14 February 2019

blood vessel remodeling

regulation of cell population proliferation

1 reference

14 February 2019

Adrenergic catecholamine trophic activity contributes to flow-mediated arterial remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

response to pain

1 reference

14 February 2019

The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

maternal behavior

1 reference

14 February 2019

Impaired maternal behavior in mice lacking norepinephrine and epinephrine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

positive regulation of vasoconstriction

1 reference

14 February 2019

Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

behavioral response to ethanol

1 reference

14 February 2019

Ethanol-associated behaviors of mice lacking norepinephrine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

leukocyte mediated immunity

1 reference

14 February 2019

Dopamine beta-hydroxylase deficiency impairs cellular immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

leukocyte migration

1 reference

14 February 2019

Adrenergic catecholamine trophic activity contributes to flow-mediated arterial remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

norepinephrine biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

8 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

Noradrenaline is essential for mouse fetal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

Dopamine beta-hydroxylase deficiency impairs cellular immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

octopamine biosynthetic process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

dopamine catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

6 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

Noradrenaline is essential for mouse fetal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

Dopamine beta-hydroxylase deficiency impairs cellular immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64237&geneProductId=UniProtKB:Q64237

octopamine metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

dopamine catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

7 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Noradrenaline is essential for mouse fetal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Dopamine beta-hydroxylase deficiency impairs cellular immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

norepinephrine biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

9 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Noradrenaline is essential for mouse fetal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Dopamine beta-hydroxylase deficiency impairs cellular immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

positive regulation of cold-induced thermogenesis

1 reference

14 February 2019

Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64237

Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site

has part(s)

1 reference

DOMON domain

1 reference

Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site

1 reference

Copper type II ascorbate-dependent monooxygenase, C-terminal

1 reference

Copper type II, ascorbate-dependent monooxygenase, N-terminal

1 reference