(Q21497929)

English

Protein phosphatase 2, regulatory subunit A, alpha

mammalian protein found in Mus musculus

PP2A subunit A isoform PR65-alpha
protein phosphatase PP2A
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
PP2A subunit A isoform R1-alpha
serine/threonine protein phosphatase A subunit type 2A
Ppp2r1a
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Armadillo-like helical

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q76MZ3

Serine/threonine-protein phosphatase 2A subunit A, metazoa

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q76MZ3

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q76MZ3

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

HEAT repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

HEAT, type 2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein serine/threonine phosphatase activity

determination method

1 reference

27 March 2018

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q76MZ3&geneProductId=UniProtKB:Q76MZ3

determination method

protein binding

determination method

9 references

8 April 2019

A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Alpha4 is an essential regulator of PP2A phosphatase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Regulation of murine cardiac 20S proteasomes: role of associating partners

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Structural Basis of PP2A Inhibition by Small t Antigen

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

protein phosphatase regulator activity

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q76MZ3&geneProductId=UniProtKB:Q76MZ3

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q76MZ3&geneProductId=UniProtKB:Q76MZ3

determination method

protein phosphatase type 2A complex

determination method

3 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q76MZ3&geneProductId=UniProtKB:Q76MZ3

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q76MZ3&geneProductId=UniProtKB:Q76MZ3

determination method

27 March 2018

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q76MZ3&geneProductId=UniProtKB:Q76MZ3

determination method

chromosome, centromeric region

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

lateral plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

protein phosphatase type 2A complex

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

determination method

4 references

8 April 2019

Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Comprehensive identification of phosphorylation sites in postsynaptic density preparations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Comprehensive identification of phosphorylation sites in postsynaptic density preparations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

biological process

regulation of meiotic cell cycle process involved in oocyte maturation

determination method

1 reference

8 April 2019

Scaffold subunit Aalpha of PP2A is essential for female meiosis and fertility in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

peptidyl-serine dephosphorylation

determination method

1 reference

8 April 2019

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

mitotic sister chromatid separation

determination method

1 reference

8 April 2019

Scaffold subunit Aalpha of PP2A is essential for female meiosis and fertility in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

meiotic spindle elongation

determination method

1 reference

8 April 2019

Scaffold subunit Aalpha of PP2A is essential for female meiosis and fertility in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

meiotic sister chromatid cohesion, centromeric

determination method

1 reference

8 April 2019

Scaffold subunit Aalpha of PP2A is essential for female meiosis and fertility in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

female meiotic nuclear division

determination method

1 reference

8 April 2019

Scaffold subunit Aalpha of PP2A is essential for female meiosis and fertility in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

chromosome segregation

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

regulation of phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

protein-containing complex assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76MZ3

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q76MZ3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q76MZ3

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000007708

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000007708

ENSMUSP00000133334

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000133334

ENSMUSP00000133778

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000133778

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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