(Q21498879)

Glycoside hydrolase, family 27

1 reference

TIM barrel

1 reference

Glycosyl hydrolase, all-beta

1 reference

alpha galactosidase family

1 reference

based on heuristic

inferred from protein domain or family

Glycoside hydrolase family 27/36, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

hydrolase activity, hydrolyzing O-glycosyl compounds

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

signaling receptor binding

2 references

3 references

alpha-galactosidase activity

15 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

alpha-Galactosidase A deficient mice: a model of Fabry disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

X-linked and autosomal genes controlling mouse alpha-galactosidase expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

X-linked inheritance of a structural gene for alpha-galactosidase in Mus musculus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Expression of alpha-galactosidase in preimplantation mouse embryos

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Comparative gene mapping: order of loci on the X chromosome is different in mice and humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Electrophoretic variation for X chromosome-linked hypoxanthine phosphoribosyl transferase (HPRT) in wild-derived mice.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Multilocus molecular mapping of the mouse X chromosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

protein homodimerization activity

IDA

hydrolase activity, acting on glycosyl bonds

ISS

ISO

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

raffinose alpha-galactosidase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

alpha-galactosidase activity

ISO

16 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

alpha-Galactosidase A deficient mice: a model of Fabry disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

X-linked and autosomal genes controlling mouse alpha-galactosidase expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

X-linked inheritance of a structural gene for alpha-galactosidase in Mus musculus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Expression of alpha-galactosidase in preimplantation mouse embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Multilocus molecular mapping of the mouse X chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Comparative gene mapping: order of loci on the X chromosome is different in mice and humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Electrophoretic variation for X chromosome-linked hypoxanthine phosphoribosyl transferase (HPRT) in wild-derived mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

2 references

2 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

1 reference

14 February 2019

Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

3 references

glycosylceramide catabolic process

5 references

24 April 2018

Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Local and global cerebral blood flow and glucose utilization in the alpha-galactosidase A knockout mouse model of Fabry disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

alpha-Galactosidase A deficient mice: a model of Fabry disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

24 April 2018

Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51569&geneProductId=UniProtKB:P51569

1 reference

14 February 2019

Infrared imaging microscopy of bone: illustrations from a mouse model of Fabry disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

negative regulation of nitric oxide biosynthetic process

1 reference

14 February 2019

Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

negative regulation of nitric-oxide synthase activity

IMP

1 reference

14 February 2019

Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

glycoside catabolic process

IMP

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

oligosaccharide metabolic process

IBA

3 references

carbohydrate metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

glycosylceramide catabolic process

6 references

14 February 2019

Local and global cerebral blood flow and glucose utilization in the alpha-galactosidase A knockout mouse model of Fabry disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

alpha-Galactosidase A deficient mice: a model of Fabry disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51569

Glycoside hydrolase family 27/36, conserved site

IBA

has part(s)

1 reference

Alpha galactosidase A, C-terminal beta-sandwich domain

1 reference