(Q21499106)

HAD-like superfamily

1 reference

P-type ATPase subfamily IIC, subunit alpha

1 reference

P-type ATPase, transmembrane domain superfamily

1 reference

P-type ATPase, cytoplasmic domain N

1 reference

HAD superfamily

1 reference

Cation-transporting P-type ATPase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cation-transporting P-type ATPase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

3 references

14 February 2019

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6PIE5&geneProductId=UniProtKB:Q6PIE5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

P-type sodium:potassium-exchanging transporter activity

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6PIE5&geneProductId=UniProtKB:Q6PIE5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6PIE5&geneProductId=UniProtKB:Q6PIE5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6PIE5&geneProductId=UniProtKB:Q6PIE5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6PIE5&geneProductId=UniProtKB:Q6PIE5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6PIE5&geneProductId=UniProtKB:Q6PIE5

P-type sodium:potassium-exchanging transporter activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

P-type potassium transmembrane transporter activity

IBA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

integral component of membrane

cell component

2 references

3 references

1 reference

11 October 2018

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6PIE5&geneProductId=UniProtKB:Q6PIE5

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

1 reference

14 February 2019

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

negative regulation of cytosolic calcium ion concentration

HDA

biological process

1 reference

14 February 2019

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice

neurotransmitter uptake

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

1 reference

14 February 2019

The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

regulation of vasoconstriction

cellular response to steroid hormone stimulus

IGI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

negative regulation of heart contraction

IDA

1 reference

14 February 2019

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

regulation of the force of heart contraction

1 reference

14 February 2019

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

regulation of muscle contraction

1 reference

14 February 2019

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

regulation of respiratory gaseous exchange by nervous system process

regulation of blood pressure

2 references

1 reference

14 February 2019

The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

negative regulation of striated muscle contraction

IGI

1 reference

14 February 2019

The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

adult locomotory behavior

1 reference

14 February 2019

Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

regulation of smooth muscle contraction

1 reference

14 February 2019

Na(+) pump alpha 2-isoform specifically couples to contractility in vascular smooth muscle: evidence from gene-targeted neonatal mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

regulation of striated muscle contraction

1 reference

14 February 2019

The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

1 reference

14 February 2019

Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

establishment or maintenance of transmembrane electrochemical gradient

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

potassium ion transport

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

3 references

response to glycoside

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6PIE5

cellular sodium ion homeostasis

3 references

cellular potassium ion homeostasis

3 references

sodium ion export across plasma membrane

3 references

potassium ion import across plasma membrane

3 references

P-type ATPase, phosphorylation site

1 reference

Cation-transporting P-type ATPase, C-terminal

1 reference

Cation-transporting P-type ATPase, N-terminal

1 reference