(Q21980297)

http://www.ebi.ac.uk/interpro/protein/P56695

Tetratricopeptide-like helical domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P56695

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

integral component of membrane

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

endoplasmic reticulum membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

integral component of endoplasmic reticulum membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

ISS

endoplasmic reticulum

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

integral component of synaptic vesicle membrane

IDA

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56695&geneProductId=UniProtKB:P56695

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

negative regulation of neuron apoptotic process

ISO

biological process

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

9 May 2019

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

IMP

calcium ion homeostasis

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

positive regulation of growth

protein stabilization

3 references

nervous system process

1 reference

9 May 2019

Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

endoplasmic reticulum calcium ion homeostasis

IMP

response to endoplasmic reticulum stress

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

IDA

regulation of cell cycle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

endoplasmic reticulum unfolded protein response

NAS

1 reference

9 May 2019

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

ubiquitin-dependent ERAD pathway

IMP

3 references

renal water homeostasis

negative regulation of programmed cell death

positive regulation of protein ubiquitination

3 references

negative regulation of type B pancreatic cell apoptotic process

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

4 references

9 May 2019

Wolfram syndrome 1 (Wfs1) gene expression in the normal mouse visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

positive regulation of calcium ion transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56695