(Q21981083)

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1 reference

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

1 reference

SH2 domain superfamily

1 reference

C2 domain superfamily

1 reference

PH-like domain superfamily

1 reference

EF-hand domain pair

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

pleckstrin homology domain, protein family

1 reference

SH2 domain, protein family

1 reference

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain, protein family

1 reference

C2 domain, protein family

1 reference

PLC-gamma, C-terminal SH2 domain, protein family

1 reference

Phosphatidylinositol-specific phospholipase C, X domain, protein family

1 reference

PLC-gamma, N-terminal SH2 domain, protein family

1 reference

Phospholipase C, phosphatidylinositol-specific, Y domain, protein family

1 reference

SH3 domain, protein family

1 reference

signal transducer activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

5 references

24 April 2018

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

phosphoric diester hydrolase activity

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice

phospholipase C activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

phosphatidylinositol phospholipase C activity

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

phosphatidylinositol phospholipase C activity

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

6 references

14 February 2019

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

B cell receptor signaling pathway

IBA

biological process

1 reference

14 February 2019

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

release of sequestered calcium ion into cytosol

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

intracellular signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

inositol trisphosphate biosynthetic process

1 reference

11 October 2018

Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

positive regulation of receptor internalization

1 reference

14 February 2019

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

2 references

lipid catabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

follicular B cell differentiation

1 reference

14 February 2019

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

response to lipopolysaccharide

1 reference

14 February 2019

Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

phospholipid catabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

regulation of gene expression

1 reference

14 February 2019

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

phosphatidylinositol biosynthetic process

3 references

negative regulation of programmed cell death

1 reference

14 February 2019

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

B cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

T cell receptor signaling pathway

1 reference

14 February 2019

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

activation of store-operated calcium channel activity

1 reference

14 February 2019

Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

positive regulation of type I interferon production

1 reference

14 February 2019

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

2 references

positive regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

response to magnesium ion

ISO

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

release of sequestered calcium ion into cytosol

ISO

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

inositol trisphosphate biosynthetic process

IBA

IBA

phosphatidylinositol-mediated signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

1 reference

Phospholipase C, phosphatidylinositol-specific, Y domain

1 reference

SH3 domain

1 reference

pleckstrin homology domain

1 reference

C2 domain

1 reference

Phosphatidylinositol-specific phospholipase C, X domain

1 reference

PLC-gamma, N-terminal SH2 domain

1 reference

PLC-gamma, C-terminal SH2 domain

1 reference

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain

1 reference