(Q21981242)

English

Cadherin 5

mammalian protein found in Mus musculus

7B4/cadherin-5
vascular endothelial cadherin
Cdh5
cadherin-5
VE-cadherin

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Catenin binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55284

Cadherin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55284

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55284

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Cadherin, cytoplasmic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cadherin-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cadherin conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

protein binding

determination method

4 references

8 April 2019

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Association of Csk to VE-cadherin and inhibition of cell proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

VE-cadherin is a critical endothelial regulator of TGF-beta signalling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

protein phosphatase binding

determination method

1 reference

8 April 2019

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

signaling receptor binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

beta-catenin binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

cytoskeletal protein binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

transmembrane transporter binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

cadherin binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

vascular endothelial growth factor receptor 2 binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

determination method

2 references

cell-cell junction

determination method

4 references

8 April 2019

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Association of Csk to VE-cadherin and inhibition of cell proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

bicellular tight junction

determination method

1 reference

27 March 2018

Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

adherens junction

determination method

1 reference

8 April 2019

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

external side of plasma membrane

determination method

1 reference

8 April 2019

Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

determination method

1 reference

8 April 2019

Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

plasma membrane

determination method

5 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

27 March 2018

Adducin is involved in endothelial barrier stabilization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

plasma membrane

determination method

6 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Adducin is involved in endothelial barrier stabilization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

cell-cell junction

determination method

3 references

14 February 2019

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

14 February 2019

A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

14 February 2019

Association of Csk to VE-cadherin and inhibition of cell proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

catenin complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

determination method

biological process

regulation of establishment of cell polarity

determination method

3 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

27 March 2018

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

Association of Csk to VE-cadherin and inhibition of cell proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

homophilic cell adhesion via plasma membrane adhesion molecules

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

cell-cell adhesion

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

adherens junction organization

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

cell-cell adhesion mediated by cadherin

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

positive regulation of angiogenesis

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

negative regulation of inflammatory response

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

cell-cell adhesion

determination method

3 references

10 September 2018

A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

10 September 2018

Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55284&geneProductId=UniProtKB:P55284

determination method

positive regulation of establishment of endothelial barrier

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

regulation of establishment of cell polarity

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

14 February 2019

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

cell-cell adhesion

determination method

4 references

8 April 2019

A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

cell morphogenesis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

cell-cell junction assembly

determination method

regulation of establishment of cell polarity

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55284

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55284

Cadherin conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55284

Cadherin, cytoplasmic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55284

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000034339

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000034339

ENSMUSP00000147286

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000147286

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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