Wikidata

(Q21981325)

English

VANGL planar cell polarity 2

mammalian protein found in Mus musculus

  • loop tail associated protein
  • vang-like protein 2
  • Vangl2
  • vang-like 2 (van gogh, Drosophila)
  • loop-tail protein 1
  • Loop-tail-associated protein
  • van Gogh-like protein 2
In more languages

Statements

molecular function
protein binding
determination method
IPI
14 references
retrieved
9 May 2019
stated in
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals
GOA
curator
UniProt
UniProt protein ID
Q91ZD4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity
GOA
curator
UniProt
UniProt protein ID
Q91ZD4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes
GOA
curator
UniProt
UniProt protein ID
Q91ZD4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 [corrected]
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
retrieved
9 May 2019
stated in
All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IPI
cell component
plasma membrane
determination method
IBA
IDA
IEA
TAS
6 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q91ZD4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IEA
retrieved
9 May 2019
stated in
Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IDA
retrieved
9 May 2019
stated in
Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IDA
retrieved
9 May 2019
stated in
Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IBA
biological process
planar cell polarity pathway involved in neural tube closure
determination method
IGI
IMP
7 references
retrieved
9 May 2019
stated in
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IMP
retrieved
9 May 2019
stated in
Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Epidermal wound repair is regulated by the planar cell polarity signaling pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
neural tube closure
determination method
IGI
IMP
9 references
retrieved
9 May 2019
stated in
Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IMP
retrieved
9 May 2019
stated in
Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IMP
retrieved
9 May 2019
stated in
Cordon-bleu is a conserved gene involved in neural tube formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Wnt5a functions in planar cell polarity regulation in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
cochlea morphogenesis
determination method
IGI
IMP
6 references
retrieved
9 May 2019
stated in
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IMP
retrieved
9 May 2019
stated in
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IMP
retrieved
9 May 2019
stated in
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Wnt5a functions in planar cell polarity regulation in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI
retrieved
9 May 2019
stated in
Epidermal wound repair is regulated by the planar cell polarity signaling pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4
determination method
IGI

Identifiers

 
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