(Q21981345)

Protein kinase-like domain superfamily

1 reference

Fibronectin type III superfamily

1 reference

Galactose-binding-like domain superfamily

1 reference

Sterile alpha motif/pointed domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

ephrin receptor

1 reference

Sterile alpha motif domain, protein family

1 reference

Ephrin type-A receptor 8, ligand binding domain, protein family

1 reference

Tyrosine-protein kinase ephrin type A/B receptor-like, protein family

1 reference

Protein kinase domain, protein family

1 reference

Tyrosine-protein kinase, receptor class V, conserved site, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Ephrin receptor ligand binding domain, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

protein kinase activity

1 reference

14 February 2019

GPI-linked ephrin receptor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

5 references

14 February 2019

Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

transmembrane receptor protein tyrosine kinase activity

IPI

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

protein tyrosine kinase activity

2 references

2 references

ephrin receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

transmembrane signaling receptor activity

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

transmembrane-ephrin receptor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

integral component of membrane

cell component

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

early endosome membrane

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

27 March 2018

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

integral component of plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

regulation of cell adhesion mediated by integrin

biological process

1 reference

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

cellular response to follicle-stimulating hormone stimulus

1 reference

14 February 2019

The ephrin signaling pathway regulates morphology and adhesion of mouse granulosa cells in vitro

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

1 reference

14 February 2019

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

nervous system development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

substrate-dependent cell migration

1 reference

14 February 2019

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

7 November 2018

Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

positive regulation of phosphatidylinositol 3-kinase activity

IMP

1 reference

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

protein phosphorylation

1 reference

14 February 2019

regulation of cell adhesion

1 reference

14 February 2019

Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

protein autophosphorylation

peptidyl-tyrosine phosphorylation

2 references

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

neuron projection development

1 reference

14 February 2019

The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

positive regulation of MAPK cascade

1 reference

14 February 2019

The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

ephrin receptor signaling pathway

3 references

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

14 February 2019

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

negative regulation of signal transduction

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

negative regulation of apoptotic process

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

positive regulation of ERK1 and ERK2 cascade

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

Ephrin receptor, transmembrane domain

has part(s)

1 reference

fibronectin type III

1 reference

tyrosine-protein kinase ephrin type A/B receptor-like

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, receptor class V, conserved site

1 reference

sterile alpha motif domain

1 reference

ephrin receptor ligand binding domain

1 reference

tyrosine-protein kinase, active site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

Ephrin type-A receptor 8, ligand binding domain

1 reference