(Q21981482)

English

Autophagy related 5

mammalian protein found in Mus musculus

APG5-like
autophagy protein 5
Atg5

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Autophagy-related protein 5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99J83

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

Atg8 ligase activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

protein binding

determination method

5 references

14 February 2019

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

phagophore assembly site membrane

determination method

3 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99J83&geneProductId=UniProtKB:Q99J83

determination method

16 July 2018

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99J83&geneProductId=UniProtKB:Q99J83

determination method

16 July 2018

Autophagosomes form at ER-mitochondria contact sites

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99J83&geneProductId=UniProtKB:Q99J83

determination method

mitochondria-associated endoplasmic reticulum membrane

determination method

1 reference

14 February 2019

Autophagosomes form at ER-mitochondria contact sites

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

determination method

3 references

14 February 2019

Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

Atg12-Atg5-Atg16 complex

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

determination method

1 reference

14 February 2019

Functional interaction between autophagy and ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

determination method

3 references

14 February 2019

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

phagophore assembly site membrane

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Autophagosomes form at ER-mitochondria contact sites

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

biological process

protein lipidation involved in autophagosome assembly

determination method

1 reference

14 February 2019

Epigenetic regulation of autophagy by the methyltransferase G9a

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

negative regulation of histone H4-K16 acetylation

determination method

1 reference

14 February 2019

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

negative regulation of phagocytosis

determination method

1 reference

14 February 2019

Autophagy regulates phagocytosis by modulating the expression of scavenger receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

immune system process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

post-translational protein modification

determination method

1 reference

14 February 2019

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

regulation of release of sequestered calcium ion into cytosol

determination method

1 reference

14 February 2019

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

cellular response to starvation

determination method

1 reference

14 February 2019

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

determination method

1 reference

14 February 2019

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

cellular homeostasis

determination method

1 reference

14 February 2019

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

otolith development

determination method

1 reference

14 February 2019

Autophagy is essential for mouse sense of balance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

regulation of reactive oxygen species metabolic process

determination method

1 reference

14 February 2019

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

autophagosome assembly

determination method

negative thymic T cell selection

determination method

negative regulation of protein ubiquitination

determination method

1 reference

14 February 2019

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

blood vessel remodeling

determination method

1 reference

14 February 2019

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

response to fungus

determination method

1 reference

14 February 2019

Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

negative regulation of reactive oxygen species metabolic process

determination method

1 reference

14 February 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

negative stranded viral RNA replication

determination method

1 reference

14 February 2019

UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

autophagy of nucleus

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99J83&geneProductId=UniProtKB:Q99J83

determination method

heart contraction

determination method

1 reference

14 February 2019

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

positive regulation of mucus secretion

determination method

1 reference

14 February 2019

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

cellular response to nitrosative stress

determination method

1 reference

14 February 2019

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

ventricular cardiac muscle cell development

determination method

1 reference

14 February 2019

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

antigen processing and presentation of endogenous antigen

determination method

cellular response to nitrogen starvation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

apoptotic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

autophagy of mitochondrion

determination method

1 reference

16 July 2018

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99J83&geneProductId=UniProtKB:Q99J83

determination method

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

determination method

4 references

14 February 2019

Autophagy regulates phagocytosis by modulating the expression of scavenger receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

determination method

7 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

autophagosome assembly

determination method

3 references

14 February 2019

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

C-terminal protein lipidation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99J83

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000044769

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000044769

Sitelinks

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