(Q21981522)

http://www.ebi.ac.uk/interpro/protein/P47774

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

G protein-coupled receptor activity

chemokine (C-C motif) ligand 19 binding

chemokine (C-C motif) ligand 21 binding

signal transducer activity

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

chemokine receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

C-C chemokine receptor activity

3 references

31 January 2018

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

31 January 2018

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

1 reference

14 February 2019

End-binding protein 1 controls signal propagation from the T cell receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

C-C chemokine receptor activity

IPI

4 references

14 February 2019

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

C-C chemokine binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

chemokine (C-C motif) ligand 19 binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

chemokine (C-C motif) ligand 21 binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

C-C motif chemokine 19 receptor activity

3 references

integral component of membrane

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

CCR7 is involved in the migration of neutrophils to lymph nodes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

intracellular anatomical structure

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

31 January 2018

CCR7 is involved in the migration of neutrophils to lymph nodes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

external side of plasma membrane

1 reference

31 January 2018

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

intracellular anatomical structure

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47774&geneProductId=UniProtKB:P47774

G protein-coupled receptor signaling pathway

ISO

biological process

positive regulation of phagocytosis

2 references

1 reference

14 February 2019

CCR7 ligand-enhanced phagocytosis of various antigens in mature dendritic cells-time course and antigen distribution different from phagocytosis in immature dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of receptor-mediated endocytosis

NAS

1 reference

14 February 2019

CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

regulation of tolerance induction to self antigen

1 reference

14 February 2019

Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of cell motility

1 reference

14 February 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

lymphocyte migration into lymph node

1 reference

14 February 2019

CCR7 and its ligands: balancing immunity and tolerance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

homeostasis of number of cells

1 reference

14 February 2019

Differential requirement for CCR4 in the maintenance but not establishment of the invariant Vγ5(+) dendritic epidermal T-cell pool

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of interleukin-12 production

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of hypersensitivity

1 reference

14 February 2019

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of T-helper 1 cell differentiation

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of T cell receptor signaling pathway

1 reference

14 February 2019

Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

regulation of interferon-gamma production

1 reference

14 February 2019

CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

response to nitric oxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

regulation of dendritic cell dendrite assembly

1 reference

14 February 2019

CCL19 induces rapid dendritic extension of murine dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of thymocyte migration

1 reference

14 February 2019

Induction of CCR7 expression in thymocytes requires both ERK signal and Ca(2+) signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

negative thymic T cell selection

1 reference

14 February 2019

Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of immunological synapse formation

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

response to prostaglandin E

1 reference

14 February 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

lymphocyte chemotaxis across high endothelial venule

1 reference

14 February 2019

CCR7 is involved in the migration of neutrophils to lymph nodes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

response to lipopolysaccharide

1 reference

14 February 2019

CCR7 is expressed in astrocytes and upregulated after an inflammatory injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of GTPase activity

1 reference

14 February 2019

CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of dendritic cell antigen processing and presentation

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of humoral immune response

1 reference

14 February 2019

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of T cell chemotaxis

1 reference

14 February 2019

CCR7 is involved in the migration of neutrophils to lymph nodes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of T cell proliferation

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

establishment of T cell polarity

1 reference

14 February 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of neutrophil chemotaxis

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

negative regulation of leukocyte apoptotic process

1 reference

14 February 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of T cell costimulation

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

inflammatory response

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

CCR7 is expressed in astrocytes and upregulated after an inflammatory injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of macrophage chemotaxis

1 reference

14 February 2019

Myelin ingestion by macrophages promotes their motility and capacity to recruit myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development

NAS

lymph node development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

mature conventional dendritic cell differentiation

1 reference

14 February 2019

CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of filopodium assembly

1 reference

14 February 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of dendritic cell chemotaxis

1 reference

14 February 2019

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

actin cytoskeleton organization

1 reference

14 February 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

chemokine (C-C motif) ligand 19 signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

chemokine-mediated signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

chemokine (C-C motif) ligand 21 signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

3 references

14 February 2019

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

3 references

14 February 2019

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

positive regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

calcium-mediated signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47774

GPCR, rhodopsin-like, 7TM

has part(s)

1 reference

stated in

InterPro Release 71.0