(Q21981633)

Neurotransmitter-gated ion-channel transmembrane domain superfamily

1 reference

Nicotinic acetylcholine receptor

1 reference

Neurotransmitter-gated ion-channel transmembrane domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neurotransmitter-gated ion-channel ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neurotransmitter-gated ion-channel, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

acetylcholine receptor activity

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

5 references

14 February 2019

A role for LYNX2 in anxiety-related behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

A role for LYNX2 in anxiety-related behavior

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

extracellular ligand-gated ion channel activity

IPI

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

acetylcholine-gated cation-selective channel activity

9 references

14 February 2019

Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

transmembrane signaling receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

acetylcholine receptor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

integral component of membrane

cell component

acetylcholine-gated channel complex

2 references

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

postsynaptic membrane

2 references

3 references

14 February 2019

14 February 2019

Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

external side of plasma membrane

1 reference

14 February 2019

Nicotinic receptors regulate B lymphocyte activation and immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

A role for LYNX2 in anxiety-related behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

integral component of plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

acetylcholine-gated channel complex

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

4 references

14 February 2019

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

integral component of presynaptic membrane

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

integral component of postsynaptic specialization membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

regulation of dopamine secretion

biological process

1 reference

14 February 2019

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

inhibitory postsynaptic potential

1 reference

14 February 2019

Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

14 February 2019

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

regulation of membrane potential

1 reference

24 April 2018

Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

membrane depolarization

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

IGI

nervous system process

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

2 references

respiratory gaseous exchange by respiratory system

1 reference

14 February 2019

Cholinergic chemosensory cells in the trachea regulate breathing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

behavioral response to nicotine

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

14 February 2019

Nicotinic receptors regulate B lymphocyte activation and immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

neuromuscular synaptic transmission

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

14 February 2019

Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

1 reference

14 February 2019

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells

calcium ion transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

acetylcholine receptor signaling pathway

IGI

1 reference

14 February 2019

Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

ion transmembrane transport

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

excitatory postsynaptic potential

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

synaptic transmission, cholinergic

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

24 April 2018

Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70174&geneProductId=UniProtKB:O70174

positive regulation of dopamine secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

protein heterooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

regulation of acetylcholine-gated cation channel activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

3 references

chemical synaptic transmission

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

synaptic transmission, cholinergic

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

nervous system process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70174

Neurotransmitter-gated ion-channel ligand-binding domain

has part(s)

1 reference

Neurotransmitter-gated ion-channel transmembrane domain

1 reference

Neurotransmitter-gated ion-channel, conserved site

1 reference