(Q21982734)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O70161

Phosphatidylinositol-4-phosphate 5-kinase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O70161

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Phosphatidylinositol-4-phosphate 5-kinase, core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

1-phosphatidylinositol-4-phosphate 5-kinase activity

Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

14 February 2019

14 February 2019

A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

14 February 2019

Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

14 February 2019

Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

talin binding

1 reference

24 April 2018

Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70161&geneProductId=UniProtKB:O70161

protein binding

IPI

1 reference

14 February 2019

Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

phosphatidylinositol phosphate kinase activity

IPI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

focal adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

adherens junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

ruffle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

uropod

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

phagocytic cup

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

endomembrane system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

nucleoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

ISO

postsynaptic density

EXP

presynaptic endocytic zone membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

ISO

glutamatergic synapse

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

14 February 2019

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

14 February 2019

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

EXP

biological process

endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

phosphatidylinositol metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

3 references

14 February 2019

14 February 2019

A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

14 February 2019

Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

axonogenesis

1 reference

14 February 2019

A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

phosphatidylinositol biosynthetic process

platelet aggregation

1 reference

14 February 2019

Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

1 reference

14 February 2019

phosphatidylinositol phosphate biosynthetic process

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

regulation of postsynaptic neurotransmitter receptor internalization

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

14 February 2019

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

14 February 2019

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70161

Phosphatidylinositol-4-phosphate 5-kinase, core

EXP

has part(s)

1 reference

InterPro Release 71.0