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Interleukin 1 receptor-like 1
mammalian protein found in Mus musculus
lymphocyte antigen 84
interleukin-1 receptor-like 1
Protein T1
Il1rl1
Protein ST2
interleukin-33 receptor alpha chain
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P14719
part of
interleukin-1 receptor type I/II
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P14719
Toll/interleukin-1 receptor homology (TIR) domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P14719
Immunoglobulin-like fold
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P14719
Immunoglobulin-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P14719
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
Immunoglobulin subtype, protein family
1 reference
based on heuristic
inferred from protein domain or family
Toll/interleukin-1 receptor homology (TIR) domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Immunoglobulin subtype 2, protein family
1 reference
based on heuristic
inferred from protein domain or family
immunoglobulin-like domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P14719
encoded by
Il1rl1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P14719
molecular function
interleukin-33 binding
determination method
IPI
2 references
retrieved
21 June 2018
stated in
IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14719&geneProductId=UniProtKB:P14719
determination method
IPI
retrieved
21 June 2018
stated in
Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14719&geneProductId=UniProtKB:P14719
determination method
IPI
interleukin-33 receptor activity
determination method
IPI
1 reference
retrieved
21 June 2018
stated in
Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14719&geneProductId=UniProtKB:P14719
determination method
IPI
interleukin-1 receptor activity
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IEA
protein binding
determination method
IPI
3 references
retrieved
9 May 2019
stated in
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IPI
retrieved
9 May 2019
stated in
IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IPI
retrieved
9 May 2019
stated in
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IPI
interleukin-33 binding
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IBA
interleukin-33 receptor activity
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IBA
cell component
extracellular region
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P14719
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IEA
integral component of membrane
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P14719
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IEA
membrane
determination method
IDA
IEA
2 references
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P14719
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14719&geneProductId=UniProtKB:P14719
determination method
IEA
retrieved
21 June 2018
stated in
Secreted and membrane-bound isoforms of T1, an orphan receptor related to IL-1-binding proteins, are differently expressed in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14719&geneProductId=UniProtKB:P14719
determination method
IDA
external side of plasma membrane
determination method
IDA
ISO
3 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
ISO
retrieved
9 May 2019
stated in
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IDA
retrieved
9 May 2019
stated in
Stat5 expression is critical for mast cell development and survival
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IDA
extracellular space
determination method
ISO
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
ISO
plasma membrane
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P14719
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IEA
cell surface
determination method
ISO
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
ISO
extracellular matrix
determination method
IDA
1 reference
retrieved
21 June 2018
stated in
Secreted and membrane-bound isoforms of T1, an orphan receptor related to IL-1-binding proteins, are differently expressed in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14719&geneProductId=UniProtKB:P14719
determination method
IDA
membrane
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P14719
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IEA
biological process
signal transduction
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IEA
positive regulation of macrophage activation
determination method
IMP
1 reference
retrieved
9 May 2019
stated in
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IMP
negative regulation of interferon-gamma production
determination method
IGI
1 reference
retrieved
9 May 2019
stated in
IL-33 reduces the development of atherosclerosis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IGI
negative regulation of I-kappaB kinase/NF-kappaB signaling
determination method
IDA
1 reference
retrieved
21 June 2018
stated in
Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14719&geneProductId=UniProtKB:P14719
determination method
IDA
positive regulation of inflammatory response
determination method
IMP
1 reference
retrieved
9 May 2019
stated in
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IMP
cytokine-mediated signaling pathway
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IEA
positive regulation of interleukin-5 production
determination method
IGI
1 reference
retrieved
9 May 2019
stated in
IL-33 reduces the development of atherosclerosis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IGI
negative regulation of T-helper 1 type immune response
determination method
IGI
1 reference
retrieved
9 May 2019
stated in
IL-33 reduces the development of atherosclerosis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IGI
interleukin-33-mediated signaling pathway
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
IEA
negative regulation of cell population proliferation
determination method
ISO
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14719
determination method
ISO
has part(s)
immunoglobulin subtype
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P14719
immunoglobulin subtype 2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P14719
immunoglobulin-like domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P14719
Toll/interleukin-1 receptor homology (TIR) domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P14719
Identifiers
RefSeq protein ID
NP_001020773
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
17082
NP_001281100
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
17082
NP_034873
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
17082
XP_006495804
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
17082
XP_006495807
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
17082
XP_036018391
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
17082
UniProt protein ID
P14719
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P14719
Ensembl protein ID
ENSMUSP00000054914
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000054914
ENSMUSP00000095379
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000095379
ENSMUSP00000133784
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000133784
ENSMUSP00000134351
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000134351
ENSMUSP00000134225
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000134225
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