(Q21983267)

Frizzled cysteine-rich domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

Frizzled domain, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

signal transducer activity

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61086&geneProductId=UniProtKB:Q61086

transmembrane signaling receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

3 references

G protein-coupled receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

Wnt-activated receptor activity

3 references

14 February 2019

Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

lateral plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

2 references

7 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61086&geneProductId=UniProtKB:Q61086

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61086&geneProductId=UniProtKB:Q61086

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61086&geneProductId=UniProtKB:Q61086

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61086&geneProductId=UniProtKB:Q61086

5 June 2018

Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61086&geneProductId=UniProtKB:Q61086

5 June 2018

The small GTPase Rac1 regulates auditory hair cell morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61086&geneProductId=UniProtKB:Q61086

5 June 2018

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61086&geneProductId=UniProtKB:Q61086

3 references

14 February 2019

Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

IDA

presynaptic active zone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

integral component of membrane

IDA

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

The small GTPase Rac1 regulates auditory hair cell morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

integral component of membrane

IBA

hair follicle development

2 references

biological process

1 reference

14 February 2019

Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

dopaminergic neuron axon guidance

IEP

1 reference

14 February 2019

Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

positive regulation of neuroblast proliferation

1 reference

14 February 2019

Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

sympathetic ganglion development

1 reference

14 February 2019

Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

G protein-coupled receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

negative regulation of execution phase of apoptosis

1 reference

14 February 2019

Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

negative regulation of mitotic cell cycle, embryonic

1 reference

14 February 2019

Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

serotonergic neuron axon guidance

1 reference

14 February 2019

Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

establishment of planar polarity

1 reference

14 February 2019

The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

cell proliferation in midbrain

IGI

1 reference

14 February 2019

Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

Wnt signaling pathway

commissural neuron axon guidance

2 references

1 reference

14 February 2019

Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

nervous system development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

cell surface receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

IGI

inner ear morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

post-anal tail morphogenesis

IGI

1 reference

14 February 2019

Congenital hydrocephalus in genetically engineered mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

response to electrical stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

planar cell polarity pathway involved in axon guidance

1 reference

14 February 2019

Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

canonical Wnt signaling pathway

3 references

non-canonical Wnt signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61086

1 reference

GPCR, family 2-like

1 reference

Frizzled/Smoothened, transmembrane domain

1 reference