(Q21983460)

Six-bladed beta-propeller, TolB-like

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

Complement Clr-like EGF domain, protein family

1 reference

LDLR class B repeat, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

Lrp4 is a receptor for Agrin and forms a complex with MuSK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

4 references

8 April 2019

Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Lrp4 is a receptor for Agrin and forms a complex with MuSK

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VI56&geneProductId=UniProtKB:Q8VI56

Wnt-activated receptor activity

IBA

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VI56&geneProductId=UniProtKB:Q8VI56

receptor tyrosine kinase binding

IBA

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Lrp4 is a receptor for Agrin and forms a complex with MuSK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

integral component of membrane

scaffold protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VI56&geneProductId=UniProtKB:Q8VI56

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VI56&geneProductId=UniProtKB:Q8VI56

animal organ development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

regulation of protein phosphorylation

1 reference

8 April 2019

Lrp4 is a receptor for Agrin and forms a complex with MuSK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

hair follicle development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

proximal/distal pattern formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

anatomical structure development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

regulation of canonical Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

negative regulation of Wnt signaling pathway

1 reference

14 February 2019

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

embryonic digit morphogenesis

IDA

1 reference

8 April 2019

Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

Wnt signaling pathway

3 references

8 April 2019

8 April 2019

Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

BMP signaling pathway

1 reference

8 April 2019

presynaptic membrane assembly

1 reference

8 April 2019

The extracellular region of Lrp4 is sufficient to mediate neuromuscular synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

positive regulation of presynaptic membrane organization

1 reference

8 April 2019

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

multicellular organism development

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

odontogenesis of dentin-containing tooth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

positive regulation of skeletal muscle acetylcholine-gated channel clustering

1 reference

8 April 2019

LRP4 serves as a coreceptor of agrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

negative regulation of axonogenesis

1 reference

8 April 2019

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

postsynaptic membrane assembly

1 reference

8 April 2019

The extracellular region of Lrp4 is sufficient to mediate neuromuscular synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

skeletal muscle acetylcholine-gated channel clustering

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

LRP4 serves as a coreceptor of agrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

negative regulation of canonical Wnt signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

8 April 2019

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VI56

Wnt signaling pathway involved in dorsal/ventral axis specification

IDA

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VI56&geneProductId=UniProtKB:Q8VI56

protein heterotetramerization

IBA

dendrite morphogenesis

amyloid-beta clearance by cellular catabolic process

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VI56&geneProductId=UniProtKB:Q8VI56

EGF-like calcium-binding, conserved site

has part(s)

1 reference

EGF-like calcium-binding domain

1 reference

low-density lipoprotein (LDL) receptor class A repeat

1 reference

LDLR class B repeat

1 reference

EGF-like, conserved site

1 reference

Complement Clr-like EGF domain

1 reference

EGF-type aspartate/asparagine hydroxylation site

1 reference

EGF-like domain

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference