(Q21984060)

English

Glypican 3

mammalian protein found in Mus musculus

glypican-3
Gpc3

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CFZ4

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Glypican, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

peptidase inhibitor activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

peptidyl-dipeptidase inhibitor activity

determination method

heparan sulfate proteoglycan binding

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFZ4&geneProductId=UniProtKB:Q8CFZ4

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

extracellular region

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFZ4&geneProductId=UniProtKB:Q8CFZ4

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

anchored component of membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

determination method

1 reference

9 May 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

extracellular space

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFZ4&geneProductId=UniProtKB:Q8CFZ4

determination method

collagen-containing extracellular matrix

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

anchored component of plasma membrane

determination method

3 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFZ4&geneProductId=UniProtKB:Q8CFZ4

determination method

16 July 2018

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFZ4&geneProductId=UniProtKB:Q8CFZ4

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFZ4&geneProductId=UniProtKB:Q8CFZ4

determination method

anchored component of plasma membrane

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

14 February 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

extracellular region

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

anchored component of plasma membrane

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

9 May 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

biological process

body morphogenesis

determination method

1 reference

9 May 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

positive regulation of glucose import

determination method

1 reference

9 May 2019

Identification of Glypican3 as a novel GLUT4-binding protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

bone mineralization

determination method

1 reference

9 May 2019

Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

negative regulation of peptidase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

positive regulation of protein catabolic process

determination method

1 reference

9 May 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

positive regulation of smoothened signaling pathway

determination method

1 reference

9 May 2019

Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

cell proliferation involved in metanephros development

determination method

1 reference

9 May 2019

Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

kidney development

determination method

1 reference

9 May 2019

Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

lung development

determination method

1 reference

9 May 2019

Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

osteoclast differentiation

determination method

1 reference

9 May 2019

Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

mesenchymal cell proliferation involved in ureteric bud development

determination method

1 reference

9 May 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

mesonephric duct morphogenesis

determination method

1 reference

9 May 2019

Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

coronary vasculature development

determination method

1 reference

9 May 2019

Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

cell proliferation involved in kidney development

determination method

1 reference

9 May 2019

Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

positive regulation of endocytosis

determination method

1 reference

9 May 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

branching involved in ureteric bud morphogenesis

determination method

1 reference

9 May 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

negative regulation of epithelial cell proliferation

determination method

1 reference

9 May 2019

Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

positive regulation of BMP signaling pathway

determination method

1 reference

9 May 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

animal organ morphogenesis

determination method

1 reference

9 May 2019

Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

anterior/posterior axis specification

determination method

1 reference

9 May 2019

glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

negative regulation of cell population proliferation

determination method

1 reference

9 May 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

embryonic hindlimb morphogenesis

determination method

1 reference

9 May 2019

glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

regulation of signal transduction

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

response to bacterium

determination method

1 reference

9 May 2019

Impact of lactobacilli on orally acquired listeriosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

cell migration involved in gastrulation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

regulation of canonical Wnt signaling pathway

determination method

positive regulation of canonical Wnt signaling pathway

determination method

3 references

regulation of non-canonical Wnt signaling pathway

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

positive regulation of canonical Wnt signaling pathway

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

regulation of protein localization to membrane

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFZ4

determination method

Glypican, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CFZ4

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000110507

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000110507

ENSMUSP00000064131

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000064131

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