Wikidata

(Q21984376)

English

Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

mammalian protein found in Mus musculus

  • rocker
  • voltage-gated calcium channel subunit alpha Cav2.1
  • calcium channel, L type, alpha-1 polypeptide
  • BI
  • voltage-dependent P/Q-type calcium channel subunit alpha-1A
  • leaner
  • brain calcium channel I
  • tottering
  • Cacna1a
  • Calcium channel, L type, alpha-1 polypeptide isoform 4
In more languages

Statements

molecular function
voltage-gated calcium channel activity
determination method
ISS
IDA
ISO
IMP
IEA
9 references
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P97445
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
ISS
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
ISO
retrieved
24 April 2018
stated in
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
24 April 2018
stated in
Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
24 April 2018
stated in
Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
24 April 2018
stated in
Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
24 April 2018
stated in
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
IEA
retrieved
24 April 2018
stated in
Effects of expression of a mouse brain L-type calcium channel alpha 1 subunit on secretion from bovine adrenal chromaffin cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
determination method
IDA
high voltage-gated calcium channel activity
determination method
IGI
IMP
ISO
ISS
12 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97445
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
ISO
retrieved
14 February 2019
stated in
Functional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Characterization of acute somatosensory pain transmission in P/Q-type Ca(2+) channel mutant mice, leaner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IGI
voltage-gated calcium channel activity
determination method
IBA
IDA
IEA
IMP
ISO
ISS
10 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97445
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
ISO
retrieved
14 February 2019
stated in
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IEA
retrieved
14 February 2019
stated in
Effects of expression of a mouse brain L-type calcium channel alpha 1 subunit on secretion from bovine adrenal chromaffin cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IBA
cell component
biological process
regulation of membrane potential
determination method
IMP
7 references
retrieved
14 February 2019
stated in
A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Possible mechanisms underlying hyperexcitability in the epileptic mutant mouse tottering
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
adult walking behavior
determination method
IGI
IMP
11 references
retrieved
14 February 2019
stated in
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Three syndromes produced by two mutant genes in the mouse. Clinical, pathological, and ultrastructural bases of tottering, leaner, and heterozygous mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
The observation of rolling mouse Nagoya (rol), a new neurological mutant, and its maintenance (author's transl)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Pain sensitivity in mice lacking the Ca(v)2.1alpha1 subunit of P/Q-type Ca2+ channels
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Tottering--a neuromusclar mutation in the mouse. And its linkage with oligosyndacylism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IGI
retrieved
14 February 2019
stated in
L-type calcium channels contribute to the tottering mouse dystonic episodes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IGI
calcium ion transport
determination method
IBA
IEA
IMP
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
ISO
retrieved
14 February 2019
stated in
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97445
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
determination method
IBA

Identifiers

RefSeq protein ID
 
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