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(Q21984511)
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Sperm adhesion molecule 1
mammalian protein found in Mus musculus
hyaluronidase PH-20
hyal-PH20
sperm surface protein PH-20
Spam1
hyaluronoglucosaminidase PH-20
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P48794
part of
TIM barrel
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P48794
glycoside hydrolase superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P48794
Hyaluronidase PH20/Hyaluronidase-5
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P48794
membrane proteins
1 reference
based on heuristic
inferred from GOA cell component → membrane
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P48794
encoded by
Spam1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P48794
molecular function
hyalurononglucosaminidase activity
determination method
IDA
IEA
IMP
5 references
retrieved
14 February 2019
stated in
Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48794
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
retrieved
14 February 2019
stated in
Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IDA
retrieved
14 February 2019
stated in
Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IDA
catalytic activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
hydrolase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48794
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
hydrolase activity, acting on glycosyl bonds
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48794
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
cell component
membrane raft
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IDA
anchored component of membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48794
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
plasma membrane
determination method
IDA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48794
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
retrieved
14 February 2019
stated in
Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IDA
acrosomal vesicle
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IDA
membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48794
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
external side of plasma membrane
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IDA
biological process
fusion of sperm to egg plasma membrane involved in single fertilization
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
metabolism
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48794
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
cell adhesion
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48794
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
single fertilization
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IMP
carbohydrate metabolic process
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48794
determination method
IEA
Identifiers
RefSeq protein ID
NP_001073344
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
20690
NP_033267
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
20690
XP_006505088
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
20690
UniProt protein ID
P48794
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P48794
Ensembl protein ID
ENSMUSP00000031693
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000031693
ENSMUSP00000143944
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000143944
ENSMUSP00000143970
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000143970
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