(Q21984804)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QZL0

membrane protein

1 reference

inferred from GOA cell component → membrane

RHIM domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

protein kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

3 references

14 February 2019

14 February 2019

Structural insights into RIP3-mediated necroptotic signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

NF-kappaB-inducing kinase activity

1 reference

14 February 2019

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

protein binding

14 references

14 February 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Structural insights into RIP3-mediated necroptotic signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

intracellular anatomical structure

1 reference

16 July 2018

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZL0&geneProductId=UniProtKB:Q9QZL0

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation

biological process

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

amyloid fibril formation

T cell differentiation in thymus

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

protein heterooligomerization

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

regulation of interferon-gamma production

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

positive regulation of oxidoreductase activity

1 reference

14 February 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

regulation of adaptive immune response

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

spleen development

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

regulation of reactive oxygen species metabolic process

1 reference

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

regulation of activation-induced cell death of T cells

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

T cell homeostasis

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

positive regulation of necroptotic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

regulation of activated T cell proliferation

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

positive regulation of reactive oxygen species metabolic process

protein autophosphorylation

positive regulation of ligase activity

1 reference

14 February 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

necroptosis

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Caspase 8 inhibits programmed necrosis by processing CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

Mechanisms of necroptosis in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

1 reference

14 February 2019

regulation of T cell mediated cytotoxicity

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

I-kappaB kinase/NF-kappaB signaling

1 reference

14 February 2019

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

lymph node development

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

protein homooligomerization

activation of protein kinase activity

positive regulation of intrinsic apoptotic signaling pathway

1 reference

14 February 2019

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

NIK/NF-kappaB signaling

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

positive regulation of necrotic cell death

1 reference

14 February 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

cellular response to hydrogen peroxide

1 reference

14 February 2019

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

programmed necrotic cell death

1 reference

14 February 2019

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0