(Q21984941)

Ureohydrolase domain superfamily

1 reference

Histone deacetylase 5

1 reference

Histone deacetylase, glutamine rich N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

histone deacetylases

1 reference

based on heuristic

inferred from protein domain or family

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

English

molecular function

NAD-dependent histone deacetylase activity (H3-K14 specific)

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

transcription corepressor activity

histone deacetylase activity

4 references

14 February 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

protein deacetylase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

DNA-binding transcription activator activity, RNA polymerase II-specific

transcription factor binding

3 references

14 February 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

histone deacetylase binding

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

core promoter sequence-specific DNA binding

1 reference

24 April 2018

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V6&geneProductId=UniProtKB:Q9Z2V6

11 references

14 February 2019

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

IPI

protein kinase C binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

5 June 2018

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V6&geneProductId=UniProtKB:Q9Z2V6

7 references

14 February 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

1 reference

14 February 2019

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

RNA polymerase II transcription repressor complex

1 reference

14 February 2019

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

9 references

14 February 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

biological process

histone H3 deacetylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

renal tubule morphogenesis

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

regulation of myotube differentiation

1 reference

14 February 2019

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

multicellular organismal response to stress

1 reference

14 February 2019

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

regulation of transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V6&geneProductId=UniProtKB:Q9Z2V6

negative regulation of striated muscle tissue development

1 reference

14 February 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

positive regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

negative regulation of transcription by RNA polymerase II

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

cellular response to fluid shear stress

1 reference

14 February 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

negative regulation of osteoblast differentiation

1 reference

14 February 2019

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

negative regulation of gene expression

1 reference

14 February 2019

AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V6&geneProductId=UniProtKB:Q9Z2V6

nervous system development

1 reference

14 February 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

regulation of striated muscle cell differentiation

1 reference

14 February 2019

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

positive regulation of neural precursor cell proliferation

1 reference

14 February 2019

Histone demethylase LSD1 regulates neural stem cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

protein deacetylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

negative regulation of cell migration involved in sprouting angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

1 reference

14 February 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

1 reference

14 February 2019

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

negative regulation of myotube differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

regulation of skeletal muscle fiber development

1 reference

14 February 2019

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

osteoblast development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

Class II histone deacetylases: versatile regulators

B cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

Class II histone deacetylases: versatile regulators

inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

regulation of protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

negative regulation of transcription, DNA-templated

histone deacetylation

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

positive regulation of stem cell proliferation

1 reference

14 February 2019

Histone demethylase LSD1 regulates neural stem cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V6

transcription by RNA polymerase II

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V6&geneProductId=UniProtKB:Q9Z2V6

Histone deacetylase, glutamine rich N-terminal domain

chromatin organization

1 reference

Histone deacetylase domain

1 reference