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(Q21985954)
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English
Otoferlin
mammalian protein found in Mus musculus
Otof
fer-1-like protein 2
protein pachanga
otoferlin
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9ESF1
part of
C2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Otoferlin
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
Ferlin, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
C2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ferlin, second C2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ferlin, first C2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
FerIin domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ferlin, third C2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ferlin, sixth C2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ferlin, fifth C2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ferlin, fourth C2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ferlin B-domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9ESF1
encoded by
Otof
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9ESF1
molecular function
AP-2 adaptor complex binding
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IDA
calcium ion binding
determination method
IDA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
retrieved
14 February 2019
stated in
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IDA
protein binding
determination method
IPI
1 reference
retrieved
14 February 2019
stated in
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IPI
protein-containing complex binding
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
ISO
cell component
integral component of membrane
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
cell junction
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
basolateral plasma membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
synapse
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
synaptic vesicle membrane
determination method
IDA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
retrieved
14 February 2019
stated in
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IDA
endoplasmic reticulum membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
cytoplasmic vesicle
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
presynaptic active zone membrane
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IDA
cytoplasm
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
ISO
endoplasmic reticulum
determination method
IEA
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
plasma membrane
determination method
IEA
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
apical part of cell
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
ISO
basal part of cell
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
ISO
biological process
hearing
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
synaptic vesicle priming
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IMP
synaptic vesicle exocytosis
determination method
IDA
IEA
IMP
4 references
retrieved
14 February 2019
stated in
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IMP
retrieved
14 February 2019
stated in
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IEA
retrieved
14 February 2019
stated in
Calcium- and otoferlin-dependent exocytosis by immature outer hair cells
GOA
curator
UniProt
UniProt protein ID
Q9ESF1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ESF1
determination method
IDA
has part(s)
C2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
FerIin domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Ferlin, C-terminal domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Ferlin B-domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Ferlin, fifth C2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Ferlin, second C2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Ferlin, third C2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Ferlin, fourth C2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Ferlin, first C2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Ferlin, sixth C2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9ESF1
Identifiers
RefSeq protein ID
NP_001093865
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
NP_001273350
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
NP_001300696
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
NP_114081
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
XP_006504269
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
XP_006504271
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
XP_006504272
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
XP_011239104
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
XP_017176674
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
XP_017176675
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
83762
UniProt protein ID
Q9ESF1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9ESF1
Ensembl protein ID
ENSMUSP00000073803
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000073803
ENSMUSP00000110395
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000110395
Sitelinks
Wikipedia
(0 entries)
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Wikibooks
(0 entries)
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Wikinews
(0 entries)
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Wikiquote
(0 entries)
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Wikisource
(0 entries)
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Wikiversity
(0 entries)
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Wikivoyage
(0 entries)
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Wiktionary
(0 entries)
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Multilingual sites
(0 entries)
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