(Q21986192)

English

Notch 2

mammalian protein found in Mus musculus

Notch2
Motch B
neurogenic locus notch homolog protein 2
Notch gene homolog 2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Neurogenic locus Notch 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

Notch-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Notch, NODP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

Notch, NOD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Domain of unknown function DUF3454, notch, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

NF-kappaB binding

determination method

1 reference

9 May 2019

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

protein binding

determination method

4 references

9 May 2019

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

9 May 2019

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

9 May 2019

Notch signaling in kidney development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

9 May 2019

RBP-L, a transcription factor related to RBP-Jkappa

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

determination method

1 reference

9 May 2019

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

signaling receptor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

receptor complex

determination method

1 reference

9 May 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

determination method

1 reference

9 May 2019

A role for the primary cilium in Notch signaling and epidermal differentiation during skin development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

extracellular region

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

biological process

Notch signaling pathway

determination method

6 references

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

9 May 2019

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

pulmonary valve morphogenesis

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

glomerular visceral epithelial cell development

determination method

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

inflammatory response to antigenic stimulus

determination method

1 reference

9 May 2019

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

multicellular organism growth

determination method

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

placenta development

determination method

1 reference

9 May 2019

Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

placenta blood vessel development

determination method

1 reference

9 May 2019

Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

determination method

1 reference

9 May 2019

Notch signaling in kidney development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

myeloid dendritic cell differentiation

determination method

1 reference

9 May 2019

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

positive regulation of osteoclast differentiation

determination method

1 reference

9 May 2019

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

in utero embryonic development

determination method

1 reference

9 May 2019

Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

marginal zone B cell differentiation

determination method

1 reference

9 May 2019

Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

ciliary body morphogenesis

determination method

1 reference

9 May 2019

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

glomerular capillary formation

determination method

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35516&geneProductId=UniProtKB:O35516

determination method

determination method

1 reference

9 May 2019

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

proximal tubule development

determination method

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

intrahepatic bile duct development

determination method

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

determination of left/right symmetry

determination method

1 reference

9 May 2019

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

hepatocyte proliferation

determination method

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

regulation of developmental process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

humoral immune response

determination method

1 reference

9 May 2019

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

embryonic limb morphogenesis

determination method

1 reference

9 May 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

defense response to bacterium

determination method

1 reference

9 May 2019

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

bone remodeling

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

positive regulation of cell population proliferation

determination method

1 reference

9 May 2019

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

positive regulation of BMP signaling pathway

determination method

1 reference

9 May 2019

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

animal organ morphogenesis

determination method

1 reference

9 May 2019

Notch signaling in kidney development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

positive regulation of apoptotic process

determination method

1 reference

9 May 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

cholangiocyte proliferation

determination method

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

liver development

determination method

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

morphogenesis of an epithelial sheet

determination method

1 reference

9 May 2019

A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

left/right axis specification

determination method

1 reference

9 May 2019

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

liver morphogenesis

determination method

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

negative regulation of gene expression

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

positive regulation of keratinocyte proliferation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

regulation of actin cytoskeleton reorganization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination method

ankyrin repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

EGF-like calcium-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

Notch, NOD domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

EGF-type aspartate/asparagine hydroxylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

Notch, NODP domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

Domain of unknown function DUF3454, notch

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35516

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000078741

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000078741

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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