(Q21986264)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

protein kinase activity

1 reference

9 May 2019

protein serine/threonine kinase activity

7 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

Ubiquitin is phosphorylated by PINK1 to activate parkin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

magnesium ion binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

protein kinase activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

protein serine/threonine kinase activity

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Ubiquitin is phosphorylated by PINK1 to activate parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

protein-containing complex binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

TORC2 complex binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

mitochondrial outer membrane

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

integral component of membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

mitochondrial inner membrane

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

mitochondrial outer membrane translocase complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

negative regulation of neuron apoptotic process

ISO

biological process

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

cellular response to toxic substance

1 reference

9 May 2019

Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

positive regulation of catecholamine secretion

1 reference

9 May 2019

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

positive regulation of translation

1 reference

9 May 2019

Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

protein phosphorylation

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

27 February 2018

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

positive regulation of dopamine secretion

1 reference

9 May 2019

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

cellular response to hypoxia

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

positive regulation of protein dephosphorylation

1 reference

9 May 2019

Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

regulation of neuron apoptotic process

1 reference

9 May 2019

Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

positive regulation of mitochondrial electron transport, NADH to ubiquinone

1 reference

9 May 2019

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

positive regulation of synaptic transmission, dopaminergic

protein ubiquitination

1 reference

9 May 2019

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

1 reference

9 May 2019

Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

regulation of hydrogen peroxide metabolic process

1 reference

9 May 2019

Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

protein stabilization

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

positive regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

respiratory electron transport chain

1 reference

9 May 2019

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

intracellular signal transduction

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

positive regulation of histone deacetylase activity

1 reference

9 May 2019

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

autophagy of mitochondrion

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

cellular response to oxidative stress

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

negative regulation of apoptotic process

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

negative regulation of gene expression

1 reference

27 February 2018

BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

cellular response to hydrogen sulfide

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

negative regulation of neuron death

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

positive regulation of NMDA glutamate receptor activity

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MQ3&geneProductId=UniProtKB:Q99MQ3

protein phosphorylation

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MQ3