(Q21986309)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22858

1 reference

21 March 2016

language of work or name

1 reference

21 March 2016

language of work or name

English

molecular function

peptide hormone receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

IBA

hormone activity

PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22858&geneProductId=UniProtKB:P22858

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22858&geneProductId=UniProtKB:P22858

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22858&geneProductId=UniProtKB:P22858

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22858&geneProductId=UniProtKB:P22858

16 July 2018

hormone activity

PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

IBA

cell component

Golgi apparatus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

intracellular anatomical structure

1 reference

10 September 2018

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22858&geneProductId=UniProtKB:P22858

nucleoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

1 reference

8 April 2019

extracellular space

1 reference

8 April 2019

PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

1 reference

8 April 2019

cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

biological process

surfactant homeostasis

1 reference

8 April 2019

Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

skeletal system development

Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

8 April 2019

PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

8 April 2019

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

bone mineralization

1 reference

8 April 2019

PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

endoderm development

1 reference

8 April 2019

Identification of two distinct functions for TGF-beta in early mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

epithelial cell differentiation

1 reference

8 April 2019

Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

protein processing

1 reference

8 April 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

endochondral ossification

1 reference

8 April 2019

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

negative regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

nipple sheath formation

1 reference

8 April 2019

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

negative regulation of chondrocyte differentiation

Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

8 April 2019

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

8 April 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

IGI

8 April 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

positive regulation of cell population proliferation

1 reference

8 April 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

regulation of gene expression

1 reference

8 April 2019

Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

osteoblast development

1 reference

16 July 2018

The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22858&geneProductId=UniProtKB:P22858

lung alveolus development

1 reference

8 April 2019

Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

mammary gland bud elongation

1 reference

8 April 2019

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

magnesium ion homeostasis

1 reference

8 April 2019

Parathyroid hormone regulates fetal-placental mineral homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

phosphate ion homeostasis

1 reference

8 April 2019

Parathyroid hormone regulates fetal-placental mineral homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

calcium ion homeostasis

1 reference

8 April 2019

Parathyroid hormone regulates fetal-placental mineral homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858

negative regulation of chondrocyte development

1 reference

8 April 2019

Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22858