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(Q21987183)
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English
Leucine-rich repeats and immunoglobulin-like domains 2
mammalian protein found in Mus musculus
leucine-rich repeats and immunoglobulin-like domains protein 2
Lrig2
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q52KR2
part of
Leucine-rich repeat domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
Immunoglobulin-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
Immunoglobulin-like fold
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
Immunoglobulin I-set, protein family
1 reference
based on heuristic
inferred from protein domain or family
Immunoglobulin subtype, protein family
1 reference
based on heuristic
inferred from protein domain or family
Immunoglobulin subtype 2, protein family
1 reference
based on heuristic
inferred from protein domain or family
Cysteine-rich flanking region, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
immunoglobulin-like domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Leucine-rich repeat, typical subtype, protein family
1 reference
based on heuristic
inferred from protein domain or family
Leucine-rich repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q52KR2
encoded by
Lrig2
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q52KR2
molecular function
signaling receptor binding
determination method
IPI
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IPI
protein binding
determination method
IPI
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IPI
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q52KR2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IEA
integral component of membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q52KR2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IEA
plasma membrane
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q52KR2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IEA
membrane
determination method
IDA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q52KR2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IEA
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IDA
growth cone
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IDA
neuron projection
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IDA
neuronal cell body
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IDA
intracellular vesicle
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IDA
extracellular space
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IBA
extracellular matrix
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IBA
biological process
regulation of platelet-derived growth factor receptor signaling pathway
determination method
IGI
1 reference
retrieved
14 February 2019
stated in
Lrig2-deficient mice are protected against PDGFB-induced glioma
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IGI
innervation
determination method
IGI
1 reference
retrieved
14 February 2019
stated in
In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IGI
hearing
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IMP
negative regulation of neuron projection development
determination method
IGI
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IGI
regulation of axon regeneration
determination method
IGI
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IGI
negative regulation of axon regeneration
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IMP
negative regulation of membrane protein ectodomain proteolysis
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IMP
positive regulation of protein localization to cell surface
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IMP
regulation of neuron migration
determination method
IGI
IMP
2 references
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IMP
retrieved
14 February 2019
stated in
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q52KR2
determination method
IGI
has part(s)
immunoglobulin subtype
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
Leucine-rich repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
cysteine-rich flanking region, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
immunoglobulin subtype 2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
leucine-rich repeat, typical subtype
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
immunoglobulin-like domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
immunoglobulin I-set
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q52KR2
Identifiers
RefSeq protein ID
NP_001020238
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
269473
NP_001297627
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
269473
XP_006501607
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
269473
XP_017175091
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
269473
XP_030108494
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
269473
XP_036019020
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
269473
UniProt protein ID
Q52KR2
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q52KR2
Ensembl protein ID
ENSMUSP00000035999
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000035999
ENSMUSP00000142373
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000142373
ENSMUSP00000142540
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000142540
ENSMUSP00000143406
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000143406
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